COVID-Induced Brain Fog Linked to Evident Blood-Brain Barrier Disruption–Study

A compromised blood brain barrier allows harmful substances to enter the brain causing disorders of the central nervous system including brain fog.
COVID-Induced Brain Fog Linked to Evident Blood-Brain Barrier Disruption–Study
The latest research suggests that brain fog caused by the COVID-19 virus is related to disruption of the blood-brain barrier. Pavlova Yuliia/Shutterstock
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Though brain fog isn’t a medical term, you know it when you have it—thoughts seem sluggish, thinking feels muddled, and your brain just feels foggy. Also referred to as “clouding of consciousness,” brain fog is a common symptom of long COVID. New research suggests that a compromised blood-brain barrier is one of the causes of brain fog.

The blood-brain barrier (BBB) is composed of brain endothelial cells and surrounding cells, serving as a barrier between the bloodstream and the brain. When the BBB is compromised, harmful substances from the bloodstream can enter the brain, often resulting in central nervous system disorders.

The Study

A study published in Nature Neuroscience in February found that patients in the acute phase of COVID-19 infection and those experiencing brain fog as a symptom of long COVID exhibited evident blood-brain barrier disruption.
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