Calorie Restriction May Cause Long-Term Weight Gain

Exercise paired with a protein-dense and low-glycemic-load diet may be the key to losing weight and keeping it off.

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You might think the key to weight loss is eating less and moving more. If a modest calorie deficit is effective for weight loss, a bigger one must lead to even better results. But the truth is that eating too little can hurt your weight-loss efforts, especially in the long run.

When you severely cut calories, your body doesn’t celebrate the deficit; instead, it fights back. Hunger roars, hormones shift, and your metabolism slows to a crawl as if your body is pulling an emergency brake. The result? A diet that might seem like a quick fix, but in the end, extracts a heavy toll: short-term gain with a long-term cost.

The Minnesota Starvation Experiment

The 1950 Minnesota Starvation Study revealed the profound effects of severe calorie restriction. In the study, participants’ calorie intake was reduced by 40 percent, leading to an average weight loss of 25 percent. However, the impact extended far beyond physical changes.

The young men enrolled in the study became intensely preoccupied with food—meals dominated their thoughts, conversations, and even their dreams and daydreams. Their interest in food grew so strong that some developed new hobbies, such as collecting recipes and reading cookbooks, and a few even shifted careers, becoming chefs.

During the rehabilitation phase, when the men were allowed to eat normally again, many began overeating, which led to issues such as headaches and digestive upset. Some even developed binge-eating tendencies and exhibited purging behaviors. Even five months into the refeeding process, these disordered behaviors around food persisted.

By the end of the study, the men’s basal metabolic rate (BMR)—the amount of energy needed to fuel the body at rest—had decreased by 40 percent, as had their muscle mass.

It should be noted that although the Minnesota Starvation Experiment offered valuable insights into the effects of starvation, the ethics of the research is staunchly debated. Such an experiment likely would not be performed today.

Sluggish Metabolism

Allison Arnett, a Texas-based family nurse practitioner, bariatric nurse, and advanced practice provider of obesity medicine, told The Epoch Times that the TV series “The Biggest Loser” is a good example of this phenomenon.

“Contestants were highly restricted in their food consumption and were aggressively working out. When they returned to their pre-show lives, they regained weight fairly rapidly due to the substantial impact the aggressive change in diet had on their metabolism,” she said.

“Short periods of fasting appear to be good for metabolic health, but long periods of not eating enough can damage the metabolic system and cause significant issues with maintaining a healthy lifestyle.”

After losing weight and fat mass, the body attempts to maintain a lower energy expenditure. This results in a slower heart rate, reduced body temperature, and a sluggish metabolism while preserving triglycerides to support essential biological functions. This response acts as an evolutionary defense mechanism designed to protect the body during food scarcity. 

“When we don’t get enough food, our bodies adapt by reducing energy use for nonessential functions, such as reproduction. This helps us conserve energy for the most vital processes needed for survival,” Theresa Gentile, a registered dietician nutritionist and spokesperson for the Academy of Nutrition and Dietetics, told The Epoch Times.

When metabolism slows down, weight regain is likely to occur thereafter. Moreover, even when the weight is regained, the metabolic rate often doesn’t fully recover.

This phenomenon, known as metabolic adaptation, can persist for up to nine years after the intervention. In contrast, no metabolic adaptation occurs in someone who hasn’t undergone calorie restriction, meaning those who don’t calorie-restrict their diets may be in a better metabolic position than those who do.

Metabolic Hormones

Metabolic hormones influence hunger and satiety and contribute to weight regain after calorie restriction. When fat is lost, levels of leptin—the hormone responsible for signaling satiety—decrease. This means that the lower your fat reserves, the fewer signals are sent to the brain to indicate fullness. With reduced leptin levels, feelings of satiety diminish, leading to increased hunger and greater energy intake.

Research shows that appetite-stimulating hormones remain affected even a year after calorie restriction. These include ghrelin (the “hunger hormone”), leptin, insulin, and peptide YY, all of which regulate satiety and energy balance.

After a period of calorie restriction, the body tends to prioritize fat deposition as soon as food becomes available again, anticipating potential future deprivation.

Therefore, reducing calories may have only a limited short-term impact. That is because the body’s mechanisms for maintaining weight are often overlooked.

While excessive calorie intake may contribute to weight gain for some individuals, simply reducing calories may not be the best solution. It might seem counterintuitive, but adequate calories and nutrients are essential for sustainable and healthy weight loss.

Starvation Causes Stress and Cognitive Issues

Insufficient food availability can trigger a stress response in the body, leading to an increase in stress hormones such as cortisol, which promotes the storage of visceral fat. Additionally, stress often heightens cravings for calorie-dense, quick-energy foods, making weight loss even more challenging.

Prolonged calorie restriction can also lead to adverse effects on mood, increasing the risk of depression and anxiety. Reduced glucose availability for the brain means cognitive function may also be impaired, Mary Curristin, a nutritionist at ART Health Solutions, told The Epoch Times.

Similarly, Gentile said: “If calorie restriction leads to inadequate intake of essential nutrients like B vitamins, omega-3 fatty acids, iron, and other brain-supportive nutrients, cognitive function can decline. Deficiencies in these nutrients are linked to impaired concentration, poor memory, and mood disorders like depression.”

Signs You’re Not Eating Enough

Gentile noted that the following could be additional signs that you are not eating enough:

• Constant fatigue and low energy
• Constant hunger and preoccupation with food
• Worsened sleep quality
• Decreased strength
• Cold sensitivity
• Disrupted menstrual cycle
• Brittle, dry nails and hair
• New mood swings
• Sudden injuries

Resisting Weight Regain

Increasing or maintaining physical activity after weight loss is one of the most effective strategies to counteract metabolic adaptations. Regular physical activity can enhance fat-burning and improve protein balance.

An article published in Diabetes Spectrum suggests that effective counseling on lifestyle modification includes getting up out of a chair and walking for two minutes every 30 to 60 minutes, connecting with physical activity professionals to develop personalized programs that work for the individual, using exercise applications, and participating in exercise programs in the local community.

“Physical activity of all types, including aerobic, resistance, flexibility exercises, and reduced sedentary time clearly results in multiple health benefits for individuals,” the authors wrote.

Another practical approach is to focus on the types of foods consumed rather than solely on reducing calories. For example, examining macronutrient composition or glycemic load can be beneficial. For instance, blueberries have a lower glycemic load than mangoes or bananas. Glycemic load is a tool used to estimate how much a food will affect blood sugar. The glycemic index (GI) is a scale of zero to 100; higher numbers affect blood sugar more, and lower numbers affect it less. Glycemic load, however, takes into account how many carbohydrates per serving the food contains, giving a more nuanced picture of the effect on blood sugar.

High-protein diets can increase feelings of satiety, and more energy is required to metabolize protein than carbohydrates and fats. Therefore, increasing protein intake may support long-term weight loss without slowing metabolism. Research shows that following a high-protein diet can result in less weight regain after dieting. The same benefits apply to a low-glycemic-load diet.

“The goal for weight loss is to create a slight caloric deficit, but not so much that your body enters starvation mode,” Gentile said.

“Prioritize nutrient-dense foods and incorporate strength training to help maintain muscle mass.”