Broccoli Compound May Boost Cognitive Function

Broccoli Compound May Boost Cognitive Function
'Three-day-old broccoli sprouts consistently contain 20 to 50 times the amount of chemoprotective compounds found in mature broccoli heads, and may offer a simple, dietary means of chemically reducing cancer risk.' (Shutterstock)
Joseph Mercola
10/9/2022
Updated:
10/10/2022

STORY AT-A-GLANCE

  • After just 12 weeks of supplementing with sulforaphane, which is just one of broccoli’s claims to fame, older adults experienced better cognitive function.
  • Sulforaphane also helps protect the heart, catalyzes a healthy balance of gut bacteria, and may be a weight management tool.
  • A superior choice to supplements is broccoli sprouts; they contain up to 50 times the amount of chemoprotective compounds and are easily grown indoors.
Food has a profound effect on your health—whether to prevent disease or reverse the negative effects of disease and illness. For example, decades of research have revealed the powerful effect that broccoli and other cruciferous vegetables have on several common health issues. Research1 has found that sulforaphane, one of broccoli’s claims to fame, is responsible for improving cognitive function and mood in older adults.

Other cruciferous vegetables include Brussels sprouts, cauliflower, cabbage, collards, kale, and bok choy. Broccoli has decades of research behind it showing that it’s a valuable, health-promoting food. While several compounds have demonstrated positive effects on health, one of the most widely studied is sulforaphane. The compound may be best known for its cancer-fighting properties.

For example, studies have shown that sulforaphane supports normal cell function and division while triggering apoptosis (programmed cell death) in cancers of the colon,2 liver,3 prostate,4 and breasts,5 as well as tobacco-induced lung cancer.6 While sulforaphane is helpful in the prevention of cancer, data7 also show it may also help to treat breast cancer.
Sulforaphane also increases enzymes in your liver8 that help destroy cancer-causing chemicals you may consume or be exposed to in your environment. This compound has even been called “one of the most powerful anticarcinogens found in food.”9
Research has also shown that it boosts detoxification of environmental toxins,10 and helps to prevent or treat high blood pressure,11 heart disease, Alzheimer’s disease,12 autism,13 and even schizophrenia.14

Older Adults Experience Better Cognitive Function and Mood

The featured Japanese study15 was published in Frontiers in Aging Neuroscience. The researchers used 12 weeks of supplementation and found that the participants experienced greater processing speed and a reduction in negative mood as compared to the group that received a placebo.

Researchers began with the premise from past studies showing sulforaphane with cognitive training had a positive effect on cognitive function. They sought to investigate whether consuming sulforaphane could improve cognitive performance and mood in older adults.

They used a 12-week, double-blind, randomized controlled trial in which 144 adults—73 men and 71 women—with an average age of 66.82 years were assigned to either a placebo group or a group that received sulforaphane supplementation.

The intervention group took 30 milligrams of glucoraphanin daily, which is converted to sulforaphane in the body. The researchers measured cognitive function, mood states, and serum and urine biomarkers at baseline and at the conclusion of the intervention.

The group that took the sulforaphane supplementation exhibited an improvement in cognitive processing speed and a reduction in negative mood. Additionally, the intervention group had a higher sulforaphane N-acetyl L-cysteine urine level, indicating they had consumed the glucoraphanin capsules. There were no other significant biomarkers of oxidative stress, neuroplasticity, or inflammation.

The health benefits from eating cruciferous vegetables are linked to glucosinolates,16 which are plant chemicals that are metabolized into isothiocyanates, including sulforaphane. Broccoli contains an enzyme called myrosinase that helps to break down glucosinolates into erucin or sulforaphane. The researchers concluded:17
“Although we did not find any significant changes in antioxidant response, neural plasticity, or the neuroinflammation blood parameter, these results indicate that nutrition interventions using SFN [sulforaphane] can have positive effects on cognitive functioning and mood in healthy older adults.”

Sulforaphane’s Effect on the Heart, Leaky Gut, and Obesity

Research data have shown that sulforaphane can help lower the risk of cardiovascular disease18 and reduce high blood pressure in an animal model.19 In one animal study,20 researchers sought to evaluate the efficacy of sulforaphane in the lab. Past data using exogenous antioxidants weren’t conclusive, which led the researchers to theorize that inducing endogenous antioxidant activities could have a promising cardioprotective effect.
Their theory was confirmed in the lab by demonstrating a reduction in intracellular reactive oxygen species production, which has a pathogenic response on the myocardium21 triggering damage and dysfunction. The antioxidant and anti-inflammatory properties of sulforaphane may be related to the activation of the Nrf2 pathway that acts as a defense mechanism against oxidative stress.
Another animal study22 23 identified yet another benefit from broccoli: a healthy gut. Researchers from Penn State demonstrated that broccoli may help in the treatment of colitis and leaky gut syndrome when they discovered that broccoli contains a compound called indolocarbazole (ICZ). This compound helps to catalyze a healthy balance of bacteria and supports the immune system.
Researchers swapped out 15 percent of the animal’s diet for raw broccoli,24 which is equal to about 3 1/2 cups of broccoli each day for a human. While that is quite a bit of broccoli, researchers say you can get an equivalent amount from one cup of Brussels sprouts, as this vegetable contains three times the amount of ICZ as broccoli.
Animal research25 26 has also suggested that sulforaphane can be used as a weight management tool. Mice that were fed a high fat diet with sulforaphane gained weight at a rate 15 percent slower than those getting the same diet without sulforaphane supplementation.
They also gained 20 percent less visceral fat. This fat collects around your internal organs and is particularly hazardous to your health. The researchers believe two different mechanisms were behind the results:27
  • Sulforaphane was found to speed up tissue browning. Brown fat is a beneficial type of body fat that helps you stay slim. It’s a heat-generating type of fat that burns energy rather than storing it.
  • Sulforaphane also decreased gut bacteria on the Desulfobivrionaceae family. These bacteria are known to produce toxins that contribute to metabolic endotoxemia and obesity.

Easy-to-Grow Sprouts Are a Concentrated Form of Nutrients

It has been my experience that it’s always better to get your nutrients from food as opposed to supplements whenever possible. However, there are times when it’s impractical or nearly impossible to achieve a therapeutic dose from food alone. You can get meaningful amounts of sulforaphane and diindolylmethane, or DIM, from eating broccoli, but it could be difficult to consistently eat enough to reach a therapeutic dose.
A superior alternative to a supplement is broccoli sprouts, which are far more potent than whole broccoli and allow you to eat less in terms of quantity. In a 1997 article submitted to Science Daily by Johns Hopkins Medical Institutions, the late Dr. Paul Talalay,28 then-professor of pharmacology at Johns Hopkins and researcher who launched the field of chemoprotection, wrote,29 “Three-day-old broccoli sprouts consistently contain 20 to 50 times the amount of chemoprotective compounds found in mature broccoli heads, and may offer a simple, dietary means of chemically reducing cancer risk.”

You can have a ready supply of cancer-fighting nutrients by growing sprouts at home. It’s quite easy, it can be done indoors, and you don’t need a lot of space. Although sprouts are small, they’re packed with enzymes, vitamins, minerals, and antioxidants that protect against free radical damage. When I first started sprouting seeds, I used Ball canning jars, but I’ve since switched to growing them in potting soil.

Sprouts grown in Ball jars need to be rinsed several times a day to prevent mold growth, and it’s a hassle to keep them draining in the sink and taking up space. You would also need dozens of jars to get the same amount as in just one flat tray. When sprouts are grown in soil, they can be harvested in about a week, and one pound of seeds will produce more than 10 pounds of sprouts.

Sprouts can be added to salads, sandwiches, vegetable juice, or smoothies. You can also boost the benefits of sulforaphane in broccoli and other cruciferous vegetables by pairing them with a myrosinase-containing food.30 This is the enzyme that converts the precursor glucoraphanin to sulforaphane. Foods that contain myrosinase include daikon radishes, arugula, and mustard seeds.31
Ideally, broccoli should be steamed for no more than four minutes to increase the available sulforaphane content. This eliminates a heat-sensitive, sulfur-grabbing protein that inactivates sulforaphane,32 while retaining the myrosinase in the broccoli. Without myrosinase, your body can’t absorb sulforaphane.

If you opt for boiling, blanch the broccoli for no more than 30 seconds and then immerse it immediately in cold water to stop the cooking process. If you prefer raw food, you'll get the most sulforaphane and nutrients from broccoli sprouts rather than mature broccoli.

References
Dr. Joseph Mercola is the founder of Mercola.com. An osteopathic physician, best-selling author, and recipient of multiple awards in the field of natural health, his primary vision is to change the modern health paradigm by providing people with a valuable resource to help them take control of their health.
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