As the lockdown wears on, officials and drugmakers promise that a vaccine is in sight that may finally end this pandemic. In the meantime, other avenues of treatment have emerged that may offer some hope.
The public had a glimpse of these options following President Donald Trump’s short stay at Walter Reed Medical Center, where he recovered from COVID-19.
The president’s treatment regimen included the experimental antiviral remdesivir and the steroid dexamethasone. However, Trump was keen on one drug in particular.
“I went in and I wasn’t feeling so hot, and within a very short period of time they gave me Regeneron. It’s called Regeneron. [I got] other things, too, but I think this was the key,” the president said in an Oct. 7 video posted on Twitter. “It was, like, unbelievable. I felt good immediately.”
Trump announced his authorization of free distribution of the drug (and a “very similar drug from Eli Lilly”) for hospitalized patients with COVID-19.
“And especially if you’re a senior, we’re going to get you in there quick,” Trump said. “We have hundreds of thousands of doses that are just about ready.”
So what is Regeneron? The name actually belongs to the biotechnology company that created the drug the president took. Regeneron scientists refer to the drug as REGN-COV2.
According to Dr. George D. Yancopoulos, president and chief scientific officer of Regeneron, the greatest treatment benefit was in patients who couldn’t muster an effective immune response themselves. He suggests that REGN-COV2 could provide a therapeutic substitute for those who are unable to produce the appropriate antibodies naturally.
“These patients were less likely to clear the virus on their own, and were at greater risk for prolonged symptoms,” Yancopoulos said.
Fully Human Antibodies
Like the anti-malarial drug hydroxychloroquine—another promising COVID-19 treatment Trump highlighted early in the pandemic—REGN-COV2 has also seen a lot of controversy in a short period of time. The big issue with Renegeron’s drug is the source material.You can think of REGN-COV2 as a new twist on an older method called convalescent plasma treatment—where doctors inject blood plasma from a patient who recovered from an infection into people struggling to recover. The idea behind this method is that the blood plasma of recovered patients contains the antibodies necessary to defeat the virus.
To develop the antibodies for REGN-COV2, Regeneron used a cell line derived from the kidney tissue of an aborted fetus from the 1970s. Many drug makers turn to this cell line for research, including companies working on vaccines for COVID-19.
“Uninformed commentary has emerged this morning stating that President Trump has received a medication created with the use of human embryonic stem cells,” reads the statement. “The president was not given any medicines to treat COVID-19 that involved the destruction of human life. No human embryonic stem cells or human fetal tissue were used to produce the treatments President Trump received–period.”
Instead of harvesting antibodies from a human, Regeneron uses animals—specifically, a special kind of mouse that has been genetically altered to have a more human-like immune system. Company scientists say they evaluated thousands of these “fully-human antibodies” produced by the company’s “VelocImmune” mice. REGN-COV2 is a combination of two monoclonal antibodies (known as REGN10933 and REGN10987) that were chosen for their ability to specifically block the virus that causes COVID-19.
Future of Treatment Options
As novel as it may sound, REGN-COV2 isn’t the first drug Regeneron has made in this fashion. They produced a similar drug designed to treat Ebola infection. On Oct. 14, the U.S. Food and Drug Administration approved this Ebola antibody treatment after it was shown to significantly reduce mortality rates in a clinical trial.Lilly says the study had been paused “out of an abundance of caution,” but gave no details about what prompted this move.
Of course, experimental, genetically altered pharmaceuticals aren’t the only treatments doctors and patients are trying. Unlike her husband, First Lady Melania Trump decided to “go a more natural route” with her COVID-19 treatment, “opting more for vitamins and healthy food.”
“I encourage everyone to continue to live the healthiest life they can. A balanced diet, fresh air, and vitamins really are vital to keep our bodies healthy. For your complete well-being, compassion and humility are just as important in keeping our minds strong. For me personally, the most impactful part of my recovery was the opportunity to reflect on many things—family, friendships, my work, and staying true to who you are,” she wrote.