Exploring the Role of Gut Inflammation in Depression

Addressing gut health can have a profound impact on brain function, depression, mood, energy levels, and motivation—factors that antidepressants don’t address.

The gut-brain connection. Inkoly/Shutterstock

Depression isn’t an antidepressant deficiency. In fact, for many people, the problem may stem from inflammation in their gut. For the estimated 40 percent of Americans complaining of one or more gut symptoms, depression may be one of them.

Studies have found that the inflammatory signals released in the gut can travel to the brain, affecting brain function and possibly triggering depression. Clinically, I’ve seen many patients resolve their depression simply by dampening gut inflammation.

The Relevance of Gut Inflammation in Depression Today

Depression affects more than 264 million people worldwide, making it a leading cause of disability. Its impact extends beyond the individual to families, communities, and society as a whole.