Unregulated Genetically Modified Foods Set for Your Grocery Aisle
“It seems gene editing is going to eliminate all disease,” said HBO’s John Oliver, “Or kill every last one of us.” He’s referring to gene-editing tools such as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat), and TALEN (Transcription Activator-Like Effector Nuclease), which are being used for everything from disease treatment to agriculture.Unbeknownst to many, CRISPR technology has already been used to tinker with crops and animals. In addition to altering the taste of foods, CRISPR is being used to extend shelf life and create foods that resist certain bacteria and viruses.
Avian Leukosis Virus Widespread in CAFO Poultry
Avian leukosis virus (ALV) has been plaguing the CAFO (concentrated animal feeding operation) poultry industry since it was first identified in 1991.3 The disease causes tumors to develop in the birds, along with symptoms such as weakness, loss of appetite, diarrhea, and depression.The U.S. Department of Agriculture (USDA) once required that chickens that showed signs of ALV or “lesions” (tumors) be removed from processing so they didn’t enter the food chain.
However, the National Chicken Council petitioned the USDA’s Food Safety and Inspection Service (FSIS) in March 2019 to “treat lesions that could be suspected as being caused by avian leukosis as a trimmable condition and not a condition that requires whole bird condemnation.”
On July 16, 2020, the FSIS accepted the petition, stating, “We have determined that current scientific evidence supports treating avian leukosis as a trimmable condition and that the actions requested in your petition would reduce regulatory burdens on the industry.”
Scientists Use CRISPR to Tackle Avian Leukosis
In 2018, researchers with the Czech Academy of Sciences determined that, because ALVs use specific receptor proteins to gain entry into cells, such receptors would make good targets for “biotechnological manipulation” in order to create poultry resistant to the virus. They attempted to do this using CRISPR-Cas9.CRISPR gene-editing technology brought science fiction to life with its ability to cut and paste DNA fragments and potentially eliminate serious inherited diseases. CRISPR-Cas9, in particular, has gotten scientists excited because, by modifying an enzyme called Cas9, the gene-editing capabilities are significantly improved.
In their 2018 study, published in the journal Viruses, the scientists noted that “CRISPR/Cas9-mediated knock-out or the fine editing of ALV receptor genes might be the first step in the development of virus-resistant chickens.” In a separate study published in PNAS in January 2020, the researchers demonstrated that CRISPR-Cas9 was effective in rendering chickens resistant to the J subgroup of ALV.
The researchers stated: “We introduced a single amino acid deletion into the gene encoding the receptor that is required for avian leukosis virus subgroup J to infect chicken cells. Here, we demonstrate that this mutation confers the resistance of chickens to avian leukosis virus subgroup J, an important pathogen in poultry. In addition, we present highly efficient genome-editing technology in chicken.”
They added that no visible side effects were apparent after the process, which involved deleting tryptophan residue number 38 of chNHE1 (W38), a critical amino acid for virus entry. The word “visible” is key, however, as many unexpected changes may still occur that aren’t immediately recognizable, and it’s possible for those changes to be transferred to other organisms or generations.
In an interview with Yale Insights, Dr. Greg Licholai, a biotech entrepreneur and a lecturer at Yale, said this could even lead to problems that are worse than the “cure,” such as antibiotic resistance or incurable diseases.
“That’s probably the biggest fear of CRISPR—Humans manipulating the genetic code, and those manipulations get passed on generation to generation to generation,” he said.
“We think we know what we’re doing, we think we’re measuring exactly what changes we’re doing to the genes, but there’s always the possibility that either we miss something or our technology can’t pick up on other changes that have been made that haven’t been directed by us.
Gene-Edited Chickens Also Exist That Resist Flu
Influenza spreads rapidly among CAFO birds and has the potential to be transmitted to humans. The simplest way to stop the widespread transmission of bird flu would be to change the way chickens are raised, putting them outdoors on pasture as opposed to crowded in disease-ridden CAFOs.In another project, this one funded by the USDA, researchers have added the SRY gene to cattle, which results in female cows that turn into males, complete with larger muscles, a penis, and testicles, but no ability to make sperm. Male (or male-like) cattle are more valuable to the beef industry because they get bigger faster, allowing companies to make greater profits in less time.
Other biotech companies have taken to targeting genes intended to ease animal suffering, which they believe may soften regulators and consumers who are wary of the technology. One company snipped out the genes responsible for growing horns in dairy cows, for instance, which means they wouldn’t be subjected to the inhumane ways the horns are currently removed (with no pain relief).
Gene-Edited Mushrooms and Lax Regulations
A number of gene-edited plant foods have also been developed or proposed, including non-browning mushrooms, which were created by Yinong Yang, a plant pathologist at Pennsylvania State University, in 2016 using CRISPR-Cas9. Although the “frankenfungi,” as it’s been called, has never before existed in nature, it would require no USDA approval because it does not contain foreign DNA.“Our genome-edited mushroom has small deletions in a specific gene but contains no foreign DNA integration in its genome,” Yang said in Penn State’s Ag Science Magazine. “Therefore, we believed that there was no scientifically valid basis to conclude that the CRISPR-edited mushroom is a regulated article based on the definition described in the regulations.”
Weeks after the USDA notified Yang that the gene-edited non-browning mushrooms wouldn’t require approval, it also ruled that DuPont Pioneer’s CRISPR-Cas9-edited corn would also be able to bypass regulatory approval.
Are You Already Eating Gene-Edited Soybean Oil?
A gene-edited soybean oil created by biotech company Calyxt was picked up by its first user—a Midwest company with both restaurant and food service locations, which is using it for frying as well as in dressings and sauces—in 2019. Calyxt’s soybean oil, Calyno, contains two inactivated genes, resulting in an oil with no trans fats, increased heart-healthy oleic acid and a longer shelf life.As of February 2019, more than 100 farmers in the Midwest were reportedly growing Calyxt’s high-oleic soybeans on more than 34,000 acres. In an update released on Feb. 7, Calyxt stated it had contracted 100,000 soybean acres in the U.S. for 2020, which represented 178 percent growth from the year prior.
It also received its first purchase order from a customer targeting four of its primary markets (food service, food ingredients, animal nutrition and industrial,) and is now offering one-gallon jugs of its Calyno cooking oil directly to consumers.
Unexpected Consequences, Risks Uncovered
Gene-editing, for all of its intended precision, isn’t an exact science. In animals, gene editing has led to unexpected side effects, including enlarged tongues and extra vertebrate.Without a label requirement, there’s no way for consumers to know whether they’re eating gene edited soybean oil—or one of the many future gene-edited products likely to hit the market, like “CRISPR chicken.” For now, however, gene-edited foods can’t be labeled organic, which is one more reason why seeking out organic and, even better, biodynamic foods, is so important.
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