Ever since Santiago Ramón y Cajal, the father of neuroscience, declared “nothing may be regenerated” in the adult brain, the idea that you can repair or regenerate damaged brain tissue was precluded by this central dogma. But compelling evidence for brain regeneration began to surface in the 1960s with a report by MIT scientist Joseph Altman that the hippocampus of adult rats and guinea pigs and the cortex of cats indeed underwent a process termed neurogenesis, i.e. the growth and development of nervous tissue.
In the decades that followed, more evidence began to amass showing the brain is in a continually dynamic state of self-repair and self-regeneration, relying on neural stem cells to replace and repair damaged and aged tissue. Clearly, in an era of widespread neurodegenerative disease—which the conventional medical establishment claims is incurable—this discovery is encouraging. If the brain can regenerate, the key is to find out how to prevent interference with this process and ascertain methods to increase and support its innate self-healing capacity.
It turns out there are many things that can support neurogenesis, including exercise and a compound found in turmeric known as aromatic-turmerone. This fat-soluble component appears to be an ideal candidate for enhancing the brain’s natural regenerative process.
A recent addition to this list of neurogenerative agents is sulforaphane, an incredibly powerful sulfur-containing biomolecule found in cruciferous vegetables.
A study published in the journal Genesis entitled, “Effects of sulforaphane on neural stem cell proliferation and differentiation,” reveals that sulforaphane may have significant curative properties against the underlying pathological disturbances found in common neurodegenerative diseases such as increased oxidative stress, inflammation, perturbed calcium homeostasis, and neuronal death. The authors of the study theorized that sulforaphane may mitigate these factors, along with stimulating neural stem cell (NSC) activity.
An already robust body of literature exists indicating that sulforaphane can up-regulate nuclear factor erythroid 2-related factor 2 (Nrf2), which increases innate antioxidant mechanisms, and suppress interleukin-1b (IL-1b), to exert its anti-inflammatory effects.
The new study sought to evaluate if sulforaphane is capable of protecting and regulating neural stem cells in such a way as to confer neuroprotective properties. It also sought to determine if sulforaphane’s therapeutic properties depend in some way on its Wnt signaling properties, which has been identified as a key molecular pathway involved in tissue regeneration.
Promising Results
First, the researchers determined the optimal concentration range of sulforaphane in promoting neural stem cell (NSC) growth without harming neurons. The researchers determined that “concentrations of less than 5 mM did not induce cytotoxic effects, but rather potentially promote the growth of NSCs.”
Second, the researchers determined that sulforaphane indeed modified genes in the WnT signaling pathway.
Finally, the researchers determined that exposing neural stem cells to sulforaphane resulted in their differentiation to neurons, lending powerful support to the hypothesis that sulforaphane could stimulate brain repair.
The researchers concluded that sulforaphane “represents a food-derived compound that has been successfully translated from lab bench to clinics.”
“Our data indicate that SFN [sulforaphane] is not only an Nrf2 inducer, but also a Wnt activator, which places SFN in a category distinct from other phytochemicals. The effects of SFN in restoring Wnt signaling provides a wealth of opportunities for the treatment of stem-cell-related diseases characterized by suppressed Wnt signaling. Further clinical studies are warranted to corroborate the neuroprotective effects of SFN in patients.”
I believe this research provides compelling evidence that the consumption of sulforaphane-containing foods may have therapeutic value in brain degenerative disorders. Considering that sulforaphane is a naturally occurring biomolecule that has been part of the human diet since time immemorial, it’s likely that its regular consumption via culinary practices delivers physiologically significant quantities in a delivery system—food—that is safe and effective in the prevention of disease.
Also, it is an astounding feature of this biomolecule that it has been identified to have potential value in preventing and treating about 200 different health conditions. This means that the side benefits of consuming it are orders of magnitude higher than one would anticipate if one were simply looking to consume it for one specific concern. That’s the amazing thing about healing with whole foods: Their health benefits are too vast to bottleneck into simply one or two applications.
While all cruciferous vegetables contains significant amounts of sulforaphane, the sprouts of broccoli have several orders of magnitude higher concentrations of sulforaphane versus the mature broccoli plant, gram-per-gram.
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