Rheumatoid arthritis is triggered by estrogen and progesterone hormone imbalance in women. In the study published in Nature Review, the researchers point out that sexual dimorphism has been a factor in rheumatoid arthritis for many years and can manifest itself differently in men and women. Researchers Grant Hughes and Divaker Choubey explained the differences are “likely to involve the immunomodulatory actions of sex steroids, nonhormonal factors encoded by genes on the X6 and Y4 chromosomes, and poorly understood immunological phenomena unique to pregnancy.”
Over time, female sex hormones decrease, which may cause severity of rheumatoid arthritis symptoms.
