Far and away the most common question I get from those who took one of the COVID-19 vaccines is: “How do I get this out of my body.” The mRNA and adenoviral DNA products were rolled out with no idea of how or when the body would ever break down the genetic code. The synthetic mRNA carried on lipid nanoparticles appears to be resistant to breakdown by human ribonucleases by design so the product would be long-lasting and produce the protein product of interest for a considerable time period.
This would be an advantage for a normal human protein being replaced in a rare genetic deficiency state (e.g., alpha galactosidase in Fabry’s disease). However, it is a big problem when the protein is the pathogenic SARS-CoV-2 spike. The adenoviral DNA (Janssen) should be broken down by deoxyribonuclease, however, this has not been exhaustively studied.
