High Doses of ADHD Drugs Linked to Higher Risks of Psychosis and Mania: Harvard Study

Researchers call for dose considerations in ADHD treatment as study shows 81 percent of high-dose psychosis cases might be preventable.
High Doses of ADHD Drugs Linked to Higher Risks of Psychosis and Mania: Harvard Study
Alex Di Stasi/Shutterstock
|Updated:
0:00

People taking high doses of amphetamines, often prescribed for treating attention-deficit/hyperactivity disorder (ADHD), may have higher risks of developing psychosis and mania, a new study has found.

Researchers at McLean Hospital, the largest psychiatric affiliate of Harvard Medical School, found that people taking high doses of the stimulant amphetamine, the active ingredient in ADHD drugs such as Adderall, face a 5.3-fold higher chance of experiencing a psychotic or manic episode.

Rachel Ann T. Melegrito
Rachel Ann T. Melegrito
Author
Rachel Melegrito worked as an occupational therapist, specializing in neurological cases. Melegrito also taught university courses in basic sciences and professional occupational therapy. She earned a master's degree in childhood development and education in 2019. Since 2020, Melegrito has written extensively on health topics for various publications and brands.