Vitamin B3 Derivative May Help Reverse Premature Aging

Rare aging syndrome study points to wider therapeutic potential.

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A landmark clinical trial from Japan found that nicotinamide riboside, a derivative of vitamin B3 (also called nicotinic acid or niacin), may have anti-aging effects.

Researchers tested a nicotinamide riboside supplement on people with Werner Syndrome, a rare genetic condition that accelerates aging, thus causing skin ulcers, arterial stiffness, and kidney disease. When the participants took it, several aspects of the disease improved—all without serious side effects. The results indicated that nicotinamide riboside supplements may be a valuable treatment for Werner Syndrome, and the authors wondered whether it has broader anti-aging implications.

A New Outlook for Premature Aging Disorders

Werner Syndrome is an incurable disease causing premature signs of aging, such as gray hair. Those with the disease also exhibit age-related conditions—including cataracts and Type 2 diabetes—while still in their 20s. Other concerns include severe skin ulcers that frequently necessitate limb amputations and early death from cancer or heart disease. The average age of death for Werner Syndrome patients is 59.