New Study Recommends Less Reliance on Ventilators in Some COVID-19 Treatment Scenarios

A medical mannequin wearing a ventilator is seen in Andover, England, on April 9, 2020. (Leon Neal/Getty Images)

The death rate of COVID-19 patients could be reduced through new guidance, including using ventilators more sparingly in some cases, a team of physician-researchers said in a new study published on Tuesday in the American Journal of Tropical Medicine and Hygiene.

In the study (pdf), researchers said some oxygen-deficient COVID-19 patients may not need to be put on ventilators because they can cope remarkably well with hypoxemia, or a low level of oxygen.

“The presence of only hypoxemia should in general not trigger intubation because hypoxemia is often remarkably well tolerated,” the team wrote, with the caveat that the most appropriate timing for intubation of oxygen-deficient COVID-19 patients is “not well known at the moment.”

Medical staff receive operating instructions for a ventilator at a hospital in Hamburg, Germany, on March 25, 2020. (Axel Heimken/Pool Photo via AP)

Still, findings suggest the criteria for intubation and mechanical ventilation should be based less on the level of oxygen in the blood and more on how much difficulty breathing a patient is having.

“With the current experience, the trigger for intubation should, within certain limits, probably not be based on hypoxemia alone but more on respiratory distress and fatigue,” the researchers wrote.

Putting someone on a ventilator is an invasive process that involves intubation, which while it can save lives in patients with severe respiratory distress, it also increases the risk of damage to the lungs.

Medics intubate a gravely ill patient with COVID-19 symptoms at his home in Yonkers, New York, on April 6, 2020. (John Moore/Getty Images)

In patients that need to be put on a ventilator, steps should be taken to prevent lung damage, which can include lowering the pressure at which the oxygen is supplied to the patient, known as “driving pressure,” the team said.

“A high driving pressure is associated with poor patient outcome,” they wrote. “Our current experience is that COVID-19 patients can be ventilated with a low driving pressure less than 15 cm H2O, often as low as 5-7 cm H20.”

A limitation identified by the team is that, to date, no randomized studies have been conducted specifically targeting the driving pressure in interventions of COVID-19.

Brazilian 99-year-old former WWII combatant Ermando Armelino Piveta gestures as he leaves the Armed Forces Hospital, after being treated for COVID-19 and discharged, in Brasilia, Brazil, on April 14, 2020. (Ueslei Marcelino/Reuters)

A further key message of the new recommended strategy is that supplemental oxygen should be treated as an essential first step in the treatment of severe COVID-19 patients with hypoxemia. It should also be a primary focus in resource-limited settings where the capacity for invasive ventilation is limited.

The researchers noted that oxygen delivery can be enhanced by using a non-rebreathing mask and prone positioning of patients.

“This ventilation strategy might reduce the currently very high case fatality rate of more than 50% in invasively ventilated COVID-19 patients,” the team noted.

The CCP (Chinese Communist Party) virus, commonly known as novel coronavirus, has spread aggressively across the world.