Inflammation Messes with Your Behavior

An immune response run amok is also affecting your better judgement
By Deborah Mitchell
Deborah Mitchell
Deborah Mitchell
November 13, 2019 Updated: November 13, 2019

Recently a group of researchers reported that  messes with how people behave and is associated with impulsivity, difficulty focusing, and an inability to delay gratification (as in “I gotta have that doughnut now”). How is it possible for there to be a relationship between inflammation and behavior?

Inflammation is a natural process that wears two hats. Its good-guy hat is involved in defending your body against invasion by bacteria, viruses, and other pathogens or traumas such as cuts or falls. For example, if you cut your finger, your immune system kicks in. The damaged tissue releases substances that result in inflammation and triggers the immune system to block off the injured area, kill any invading organisms that may cause infection, get rid of the damaged tissue, and begin the healing process. As healing progresses, inflammation goes away.

Chronic inflammation, however, wears the bad-guy hat and is a different scenario. It is a sign that your body is out of balance, and it is associated with scores of health problems and diseases ranging from headaches and heart disease to arthritis and digestive problems.

Deep-seated systemic inflammation can have many causes and contributors, most of which are linked to lifestyle. At the top of the list is a poor diet (processed, refined foods, sugars, and unhealthy fats). Other factors include lack of exercise, chronic stress, insufficient sleep, alcohol and tobacco use, and food allergies. Fortunately, all of these can be modified.

Inflammation and Behavior

A group of researchers at Texas Christian University recently published a report suggesting that “inflammation may contribute to decision-making patterns that can result in undesirable personal and societal outcomes.” Put another way, inflammation seems to have an impact on how the mind makes decisions, resulting in behaviors such as impulsivity, engaging in risky behaviors such as drug use or drinking, or difficulty staying focused on activities.

Prior to this research, there’s been evidence that inflammation promotes psychological changes that can increase a person’s sensitivity to changes in their environment. For example, it seems that inflammation may have an effect on a negative experience, such as being rejected by others. However, it also may impact our positive encounters, such as receiving social support.

Inflammation and Behavior: New Study

In the new study, the authors hypothesized that inflammation would be associated with more immediate gratification. They tested this idea by looking at the relationship between inflammation and current-focused decision-making among 159 young adults (80 men, 79 women) who were told to abstain from sex, alcohol, and smoking for 48 hours before testing.

The authors measured levels of substances associated with inflammation; namely, interleukin-6, interleukin-1-beta, tumor necrosis factor-alpha, and white blood cell count after stimulation of the immune system. A technique called LPS (lipopolysaccharide) was used to promote inflammation. LPS stimulates certain immune system cells, which in turn cause the production of inflammatory mediators.

The relationship between the levels of the inflammatory substances was compared against behavioral factors, which included temporal focus, self-reported impulsivity, and self-reported inability to delay gratification.

Overall, the authors found that inflammation, even low levels in healthy people, can impact our decision-making choices, causing more impulsivity, trouble focusing on the task at hand, and delaying gratification. The experts noted that these results “suggest that the activities of the immune system may plan an important role in shaping decision-making preferences.”

The findings are important because they provide new insight into how inflammation has an impact on our behavior, which in turn suggests new ways to manage and treat social and health problems by targeting inflammation.

How You Can Reduce Inflammation

Fortunately, there are several lifestyle changes you can initiate right now to help you lower inflammation in the body and begin feeling better.

  • Avoid or significantly limit your intake of added sugars and processed foods
  • Choose whole, natural foods free of preservatives and other food additives
  • Work with a health care professional who can help you identify any nutritional deficiencies and then make adjustments to your diet, or use supplements to return your body to balance
  • Limit or avoid alcohol
  • Participate in physical activity on a daily basis, at least 30 minutes of moderate exercise 4–5 times a week
  • Engage in stress-reducing activities daily, such as meditation, tai chi, yoga, progressive relaxation, deep breathing, listening to soothing music, or other relaxing activities
  • Get 7–8 hours of sleep every night and adopt healthy bedtime and sleeping habits

Bottom Line

Inflammation appears to have a significant impact on our decision-making skills which, in turn, can have a big effect on how we behave and our interactions with others. Although much more research is needed to understand the relationship between inflammation and behavior, in the meantime everyone can take steps to reduce inflammation in their lives by adopting some general lifestyle guidelines.

Deborah Mitchell is a freelance health writer who is passionate about animals and the environment. She has authored, co-authored, and written more than 50 books and thousands of articles on a wide range of topics. This article was originally published on

Deborah Mitchell
Deborah Mitchell