What Causes Breast Cancer? Sorting Fact from Fiction

What Causes Breast Cancer? Sorting Fact from Fiction
Francesco, CC BY 2.0
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Breast cancer accounts for one in four female cancers diagnosed in Australia each year. It is estimated that by the age of 85, one in eight women will be diagnosed with breast cancer and one in 39 will die from the disease.

The diagnosis of breast cancer can be mentally distressing. And these psychosocial effects can be confounded by feelings of guilt and self-blame if the woman thinks she could have changed or avoided the factors that she believes caused her cancer.

There is considerable confusion surrounding the causes of cancer – and no wonder, given different types of cancer often have different causal agents. This confusion often deepens when you encounter the plethora of theories and unsubstantiated claims circulating on the internet.

So, what do women believe causes breast cancer? And what scientific support is there for these beliefs?

Causes and Risk Factors

To the scientist, “cause” and “risk” have precise, scientific meanings. A cause is an agent that leads to a disease or condition, either directly or indirectly. A risk is the probability that the disease or condition will arise in an individual. And a risk factor is something that increases the possibility.

But for most people, the terms “cause” and “risk” are less definite. Generally, they both signify a condition or conditions to be met before a disease develops, similar to needing to have HIV before AIDS develops.

Breast cancer is associated with a variety of factors rather than a single causal agent. These risk factors include:

  • being female (breast cancer is 100 times more common in women than men)
  • advancing age
  • genetics and family history
  • early menstruation (before the age of 12)
  • later menopause (after the age of 55)
  • hormonal status, including the use of some oral contraceptives (though this risk returns to normal over time after they’re stopped) and long-term use of hormone replacement therapy (HRT)
  • denser breast tissue
  • being overweight or obese after menopause
  • alcohol consumption (the risk rises with increased consumption)
  • ionising radiation and
  • previous cancer.

Some protective factors may decrease the risk of breast cancer:

  • childbirth
  • having four or more children
  • younger age at first birth
  • breastfeeding
  • being overweight before menopause and
  • physical activity.

Most risk factors cannot be modified to reduce the chance of developing breast cancer; many of these appear to be connected to oestrogen and androgen production and circulation.

The genetic/family history link is well-documented, although heredity is associated with only 9% of breast cancers, and having the gene mutations does not mean breast cancer is inevitable.

Breastfeeding may help protect against breast cancer. (Shutterstock*)
Breastfeeding may help protect against breast cancer. Shutterstock*
Allyson Thomson
Allyson Thomson
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