Research Discovers Cytokines Promote Blood Vessel Growth, Helps Treat Ischemic-Induced Tissue Damage

Research Discovers Cytokines Promote Blood Vessel Growth, Helps Treat Ischemic-Induced Tissue Damage
A comparison between mice with and without the IL-4 receptor (IL4Rα) after restoring blood flow to their limbs. Courtesy of CUHK
|Updated:
0:00

A study conducted at the Chinese University of Hong Kong (CUHK) revealed that certain cytokines known as IL-4 and IL-13 can activate blood vessel growth in locations where blood can’t flow. This discovery holds promise for offering new treatment directions for peripheral artery disease (PAD) and diabetes-related blood circulation problems.

PAD is a common condition involving the blockage or narrowing of blood vessels from the heart to the limbs. When individuals suffer from PAD and diabetes simultaneously, they can experience various complications, including vascular and nerve damage. Vascular damage and poor blood flow can hinder the delivery of oxygen and nutrients to the legs, leading to non-healing wounds. In severe cases, there will be tissue necrosis, necessitating amputation to prevent further complications.