The study group included 20 subjects who received two doses of an mRNA COVID-19 vaccine, 20 who were unvaccinated and tested negative for COVID-19 or antibodies indicating they had previously been infected, and a control group of 20 unvaccinated participants who tested positive for COVID-19.
Spike Protein From mRNA Differs from Post-Infection Spike ProteinAccording to the study, spike proteins originating from the translation of mRNA vaccines differ from natural spike proteins that circulate in biological fluids post-infection because two proline amino acids replaced the amino acids lysine and valine to help stabilize the synthetic spike generated by vaccination. This double amino acid variation removed a tryptic digestion site (a necessary part of protein absorption) on the natural spike protein. Because of this, researchers said it is possible to differentiate between natural and synthetic spike protein in biological fluids using tryptic digestion followed by mass spectrometry analysis.
3 Hypotheses for Persistent Synthetic Spike Protein in VaccinatedBased on the results of the study, researchers suggested three possible hypotheses to explain why synthetic spike protein persisted in the vaccinated:
- The mRNA from COVID-19 vaccines may be integrated or retranscribed in some cells.
- Pseudouridines at a particular sequence position may induce the formation of a spike protein, although the researchers stated this was a remote possibility.
- The mRNA-containing nanoparticles may be picked up by bacteria ordinarily present at the basal level in the blood and produce spike protein.
Other StudiesIn a recently published paper in Biomedicines, data show the design of the mRNA COVID-19 vaccines allows uncontrolled biodistribution, durability, and persistent bioavailability of the spike protein inside the body after vaccination.
“The lipid-nanoparticle matrix permits widespread biodistribution of mRNA gene codes to cells in most or all organs” and could potentially damage tissues and cause disease, researchers concluded.
CDC Says Vaccines Do Not Affect DNA, Despite Conflicting EvidenceThe CDC, in addition to claiming mRNA from COVID-19 vaccines quickly break down within the body, also states on its website that these vaccines “do not affect or interact with our DNA”—the genetic material contained within the nucleus of cells—because these vaccines do not “enter the nucleus of the cell.”
The agency says “messenger RNA” COVID-19 vaccines work by “delivering instructions (genetical material) to our cells to start building protection” against SARS-CoV-2, and that the body discards all vaccine ingredients after producing an immune response just as it discards “any information cells no longer need.” According to the CDC, this process is a “part of normal body functioning.”