If your children develop autoinflammatory disease, you should attentively consider their core body temperature. Autoinflammatory disease is a rare syndrome that is mostly unheard of, even by those who suffer from the disorder, causing a lack of understanding of it by family members or friends. Severe symptoms can be life-threatening. Therefore, we must pay close attention to children with periodic fever because it is not just a fever.
Elevated Temperature Is Likely an Inflammatory Flares Trigger
A recent study from the Garvan Institute of Medical Research has shown that core body temperature can be associated with mevalonate kinase deficiency (MKD). If the body temperature elevates, it may trigger inflammatory flares in patients with this rare autoinflammatory disease.MKD is an inborn error of metabolism caused by two copies of a mutant gene from each parent. This recessive disorder has mutations in genes for mevalonate kinase (an enzyme present in all cells of the body). The deficiency of this enzyme leads to the buildup of defective proteins in immune cells, thus triggering inflammation. The study is published in the Journal of Clinical Investigation.
