Faced with a monkeypox vaccine supply and demand problem, the White House's newly minted National Monkeypox Response team on Tuesday implemented a plan to stretch the current vaccine supply by up to five-fold.
The U.S. Food and Drug Administration on Tuesday issued an emergency use authorization (EUA) for the Jynneos monkeypox vaccine to be administered by intradermal injection, which requires one-fifth of the dose of a normal subcutaneous injection.
“The FDA quickly explored other scientifically appropriate options to facilitate access to the vaccine for all impacted individuals. By increasing the number of available doses, more individuals who want to be vaccinated against monkeypox will now have the opportunity to do so.”
The EUA allows for individuals aged 18 and over to receive an intradermal injection of the Jynneos vaccine between layers of the skin and for individuals younger than 18 deemed to be at high risk of monkeypox infection to receive a subcutaneous injection under the skin.
Alternative DosageThe EUA allows for health care providers to inject 0.1 mL of the Jynneos vaccine intradermally, instead of 0.5 mL injected subcutaneously.
The White House fact sheet said that two doses of an intradermal injection at a fifth of the dose produces a similar immune system response to subcutaneous dosing, citing data from a 2015 clinical study of Jynneos published in a peer-reviewed journal that it did not name.
"Additionally, data shows the intradermal administration of other vaccines such as influenza and hepatitis B, is safe and effective for immunocompromised individuals, such as people with HIV," the fact sheet reads.
"Jynneos has been tested in individuals with immunocompromising conditions and has found to be safe and effective in the trials that were performed to support approval."
Individuals will still need to get two doses given 28 days apart, and those whose first shot was subcutaneous can receive their second dose intradermally or subcutaneously.
OutbreakMonkeypox case numbers in the United States are currently over 9,400, up by almost 4,000 since Aug. 4. The first case in the United States emerged in May.
The Biden administration declared a public health emergency for monkeypox in a bid to unlock funding and more powers to deal with the virus. Some states, including New York, California, and Illinois, have declared their own public health emergencies for similar reasons.
While monkeypox is not typically considered a sexually transmitted disease, in the 2022 outbreak, the virus has primarily been spread via the sexual activity of gay and bisexual men.
The CDC and World Health Organization (WHO) have named this demographic as the most at-risk. The White House has previously identified a need for education and outreach about monkeypox to the LGBT community in order to combat the spread.
FEMA’s Robert Fenton and the CDC's Dr. Demetre Daskalakis are leading the White House's response to the monkeypox outbreak.
“These temporary changes will help slow the spread of monkeypox until vaccine supply is adequate," the CDC webpage reads.