A new British study found that the original SARS-CoV-2 virus (i.e. Wuhan strain) can impair cognitive ability in a way equivalent to making the brain age by two decades. Currently, 67 percent of the world’s population has been vaccinated against the COVID-19 pandemic. Is it possible that the vaccines themselves also can cause aging damage?
Patients’ Aging BrainsThe study was published in the journal EClinicalMedicine. Experts from the University of Cambridge and Imperial College London Medical School evaluated the cognitive effects of the COVID-19 infection in humans.
The research subjects consisted of COVID-19 patients who were hospitalized for severe illness between March and July 2020.
After these patients’ recovery from acute infection, the researchers conducted follow-up visits for an average of six months to analyze and evaluate their anxiety, depression, and post-traumatic stress. The researchers discovered a significant decline in the patients’ attention, complex problem solving skills, and memory, along with reduced accuracy, and prolonged reaction time.
These cognitive deficits are similar to the decline a person would experience between the ages of 50 to 70, which is equivalent to aging by two decades and losing 10 IQ points.
In addition, the recovery of cognitive ability is very slow in patients with COVID-19 infections.
COVID-19 Can Accelerate 'Epigenetic Aging Clock'Why does COVID-19 infection cause abnormal aging? Let’s first take a look at one concept.
The relationship between genes and epigenetics are like seeds and soil. Genes are like seeds, while epigenetics is like soil. Genes in the human body do not usually change after birth. They are like “seeds” that lie dormant in the soil, and some will grow, and some will not. What determines whether these seeds will grow or not are the genetic “switches,” or “epigenetics.”
“Epigenetics” is the study of these factors that affect genes being turned on or off. Specifically, one common type of gene switch—DNA methylation—can change the expression of genes, shutting them down and making them non-functional. Methylation is a somewhat complex biochemical process in the body, the important thing to remember is that it is one of the ways epigenetic takes place and a process by which genes get turned on and off.
As a result of DNA methylation, there are variations in whether the same genes can be expressed in different organs and at different ages, and the amount of expression.
Cells become senescent as we age. That means they stop dividing and enter a kind of stasis. Instead of dying off as they normally would, they persist, but change shape and size and secrete inflammatory molecules that cause other nearby cells to become senescent.
Human beings experience birth, aging, illness, and death, which is now discovered by our scientists to be controlled by our internal epigenetic clock. This is similar to the observations that everything in our universe has its cycle of formation, stasis, degeneration, and destruction.
These genetic focal points were carefully selected by scientists, independent of gender, body part, comorbidities, and other factors. And the results have been highly accurate, with a precision of over 95 percent in gauging a person's biological age.
Humans have a normal aging methylation curve. If a person’s DNA methylation is above the curve, he or she will age faster than his or her peers; if it is below the curve, he or she will appear younger than his or her peers.
So, what factors can accelerate aging, i.e. epigenetic clock of aging?
- Diseases: viral infections (e.g. HIV and CMV), neurodegenerative diseases, and cancers;
- Metabolic syndrome: overly high body mass index (BMI), hyperglycemia, inflammatory factors, and hypertension;
- Stress: post-traumatic syndrome, mental stress, and violence experienced in childhood.
Aging Can Be ‘Contagious’? Senescent Cells Cause 12 Major DiseasesEven after the infection is over, many people still have symptoms of “long COVID.” Is this related to the aging caused by COVID-19?
Epigenetic aging is seen in the graying of hair and loosening of teeth. However, on a cellular level, cells in the human body also gradually age.
So, what are the effects of cellular senescence on our health?
Cellular senescence plays an important role in many age-related diseases, such as degenerative diseases of the nerves, eyes, lungs, and heart.
Do the COVID-19 Vaccines Also Cause Cellular Senescence?The aforementioned study was conducted prior to the Omicron variant outbreak, and the Omicron variant is clearly less pathogenic than the old strain. In fact, some of the mutation sites of the Omicron variant counteracted the factors that caused cellular senescence. It is estimated that Omicron causes significantly less accelerated senescence or sequelae than the old strain.
However, the vaccines we are currently administering are still developed using the spike proteins of the old strain of early 2020, so is there a risk of accelerated aging?
There Is a Way to Reverse AgingReversing aging sounds like a dream come true for everyone. We have already understood so many mechanisms related to aging, so is it possible to find a way to slow down or even reverse aging?
In fact, our daily diet, work habits, and lifestyle all affect the epigenetic aging clock. For instance, during high-temperature cooking, red meat produces glycosylated end products, which are associated with cellular aging; poultry and fish are relatively healthy; and the vitamins in fruits and vegetables help keep cells young, which can help slow down or reverse the aging clock.
In addition, an article published in 2017 in the journal Psychoneuroendocrinology, American and French scholars investigated whether or not sitting in meditation affects the epigenetic aging clock.
The results showed that the epigenetic aging acceleration increased in elderly non-meditators, while the acceleration in elderly meditators was more similar to that of younger people and was not affected by the epigenetic aging effect.
Gene expression is also associated with changes in our appearance, so meditators appear younger than their actual age. Furthermore, meditators also have younger brains.
The researchers analyzed and compared the brain ages of the two groups and found that the brain age of the meditators was younger than their actual age. For instance, 50-year-old meditators had the same brain age as a 42.5-year-old non-meditator, while 60-year-old meditators had the same brain age as the 51-year-old non-meditators in the control group.
Interestingly, for the meditators over 50, each additional year of their actual age would make their brain age one month and 22 days younger than their actual age.
In summary, damage caused by SARS-CoV-2 to the human body speeds up the human epigenetic clock of aging and dumbs down the brain. Vaccines based on the old strains in 2020 may also harm the human body in this regard.
At least 67 percent of the world's people have now been vaccinated; will people in the future get older more quickly? No. It is too early to conclude anything based on cellular data alone rather than human studies. However, the cellular data is a clear reminder for us to take precautions to prevent this.
Meanwhile, it is quite worrisome that when we discussed this topic during a Health 1+1 live broadcast on July 12 2022, quite a few audience members had commented that they themselves or their friends or relatives had become obviously older after receiving the jabs.
The good news is that aging is a long process. During this process, for example, we can develop the habits of healthy living, including eating well, exercising, and daily meditation, which can help slow down or even reverse the aging process, and furthermore bring us various positive health benefits, which will be detailed in future articles.