Chronic Neuropathic Pain–Researchers Uncover Potential Non-Opioid Treatment

One of the most difficult conditions to treat, neuropathic pain is often sedated with opioids—now, on the horizon, may be a safer, non-addictive alternative.

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Researchers have discovered a new molecule that reduces hypersensitivity in mice when bound to a specific protein known to cause neuropathic pain. This revolutionary, non-opioid approach to pain management could be a game-changer for those who suffer from chronic neuropathic pain.

The study, conducted at the University of Texas and the University of Miami and published in the journal, Proceedings of the National Academy of Sciences, in December 2023 found that the molecular compound FEM-1689 effectively reduced neuropathic pain in mice with long-term results. Researchers hope to develop this compound into a drug to treat chronic neuropathic pain in humans without the dangerous side effects of opioids.

Study Findings Explained

Researchers conducted the study on mice to determine if there was a specific compound that could safely reduce neuropathic pain. The scientists specifically wanted to find a long-term neuropathic pain treatment solution that did not involve opioids.