Can immersing yourself in a South American jungle and the high-fiber, unprocessed diet of its villagers make your gut microbes more diverse? And could it have benefits for people with obesity, type 1 diabetes, and other disorders?
For the children, their microbiome—the beneficial germs in their intestines, skin, mouths, and noses—became more diverse, with higher proportions of helpful bacteria. A similar change did not occur in the adults who visited the rainforest.
Dominguez-Bello found in previous studies that the human microbiome in urbanized, more modernized societies contains a far less diverse array of species than that of people living more traditional, pre-modern lifestyles in the Amazon jungle of Venezuela and Peru.
Dominguez-Bello studies the connection between the microbiome and human health and how early impacts on the microbiome may contribute to the rise of obesity, diabetes, and other conditions in developed countries.
The subjects of the new experiment stayed in a rainforest village in southern Venezuela near the border with Brazil. Their daily diet consisted of cassava, fish, a little meat, and a lot of fruit. They adopted the local circadian rhythm with eight hours of sleep and bathed in a river without soap.
Researchers swabbed the subjects’ skin, nostrils, mouths, and feces for microbe samples several times during the study, and compared them with samples from villagers. Rutgers–New Brunswick postdoctoral fellow Jincheng Wang participated in the analysis, which found that the urban visitors began with a less diverse microbiome than that of the locals. Over the 16 days, the urban children—but not the adults—showed significant microbiome changes, though the health implications are uncertain.
Dominguez-Bello said more research is needed to better understand the “age window” at which the microbiome can change, and to separate the various factors—diet, day/night cycles, physiology, and others—that may affect these changes.