Endocrine Disruptors Sabotage the Male Fetus
In the dark warmth of the womb, a miracle unfolds silently and inexorably. An unrecognizable glom of cells begins to take shape according to a master plan laid down eons ago. The tiny mass that will soon form a priceless treasure burgeons into human form with fingers, toes, and a minuscule nose. It is female, and only nature can read the instructions that determine whether the being remains female or transforms into a male.Where Are the Boys?
As early as April of 1998, the Journal of the American Medical Association quietly released a special report that revealed puzzling news. The number of males born in industrialized nations has dropped dramatically since 1970, constituting a serious reversal in earlier trends. Records up to 2014 show that trend continuing.Human male births have always held a marginal advantage, probably Nature’s way of insuring that enough of the somewhat more physically vulnerable male infants will survive. Earlier last century, between 1900 and 1950, typically as many as 106 males to every 100 female babies were born, probably because obstetrical practices improved so much that more male babies survived pregnancy and delivery. Census figures after 1970 indicate a trend reversal, a significant reduction in the number of little boys born. Today in industrialized nations, including Canada, the U.S.A., Sweden, and the Netherlands, that ratio has dropped significantly, a shift which over four decades translates to at least one male less in 1000 births or about 80,000-100,000 fewer males in a population as large as the U.S.A. Over the world that adds up significantly, creating a red flag for humanity.
Although in a population of 325 million, 80,000 seems like a drop in the proverbial bucket, the real mystery exists in what is happening to these little boys. While it may seem counter-intuitive, top environmental scientists say these little boys may be being born female.
This revelation comes as no surprise to anyone who understands fetal development. Gonadal cells that build male and female sex organs proliferate more rapidly than most other cells, such as bone or muscle, in a developing fetus. And, according to Dr. Devra Davis, founder of the Environmental Health Trust, since rapidly dividing cells are more likely to “incorporate and replicate errors,” these fast growing sexual organs are extremely susceptible to synthetic chemicals capable of converting genetic boys into girls and feminizing male babies.
Turning Boys Into Girls
Within six weeks of conception, the flourishing embryo, in an exuberant burst of life, grows a heart, mouth, limbs, eyes, muscles, a set of unisex gonads and two pairs of genital tubes, one male, one female. The next step is genital growth.Near the close of the pregnancy’s second month, the baby starts developing sexual organs. Inherently poised to construct a little girl, the baby’s body begins executing the female program unless specifically interrupted by male hormonal cues which should be transmitted if the baby is genetically male. If no male instructions are forthcoming, the pea-sized embryo generates female organs, ignoring the child’s genetic blueprint for male (XY) or female (XX). The male tubes dissolve, leaving the female tubes to metamorphose, sprouting oviducts, fallopian tubes, uterus, and vagina. The gonads, neurally wired for either gender, flower into ovaries.
If, however, the baby is genetically male, with both an X and a Y chromosome, and all goes as planned, around day 51 the Y, or male designating chromosome, signals the gonad’s Sertoli cells to blast the female organs with an anti-feminine secretion called AFH. The object is halting female development so male construction can proceed. Under this barrage, the female ducts shrivel like abandoned fruit, almost disappearing within days. With these structures out of the way, the female volition is sapped, allowing the evolution of male sex organs from the androgynous gonads.
Once the gonads emerge as testes, these near microscopic male organs discharge the male hormone, testosterone, driving the cultivation of even more male features. Testosterone first directs the male ducts to build a bridge between the baby’s testes and ejaculatory duct, via a tube called the ductus deferens. Afterwards, testosterone action propels the testes into the scrotum, providing the baby with a full set of male equipment.
Epigenetics of Male Genital Disruption
But what could block the male instructions programmed into XY chromosomes long before our ancestors stood on two feet? The answer is anything that affects the human hormones these sex chromosomes command.Male genital construction depends upon sex, or steroid, hormones which mandate the male baby develop a penis and testicles. Since testosterone, estrogen, and AMH are all steroid hormones, anything that modifies levels of these hormones, can invert the normal sexual development of a male baby. EDCs which are structurally very similar to steroid hormones can subvert this process. Sexual inversion, or the failure to develop sexual organs, preference, or behaviors in accordance with one’s genetic sex, creates an incongruity in the baby’s sexual makeup when the hormone plan is corrupted.
Timing is crucial. Genital development transpires during critical phases in which the right hormone must hit the right place in the right proportions. Like a vehicle entering heavy traffic, a lack of power, an error in perception, or a timid driver, can create a disaster. However, once the hormonal hit is made, it is irreversible. Male anatomy is either initiated or diverted.
Synthetic chemicals can create these silent switches in Nature’s plan. EDCs we encounter every day can alter the sex hormone balance, preventing male genitals from growing properly. By suppressing testosterone or by enhancing or mimicking the female sex hormone, estrogen, they can undermine the natural testosterone messages surging through a growing fetus.
For instance, estrogen mimics like dioxin, a widespread pollutant and potent endocrine disruptor, can intercept and overcome a hormonal message from a male gene. Dioxin also acts as a testosterone flusher reducing male hormone concentrations so much that the male action may not be stimulated adequately. Testosterone suppressors like DDT can block testosterone’s position on a receptor. Hormone stimulators can intensify the action of a natural hormone so much that the system shuts down and refuses to receive a male “go ahead” signal.
The EDC Disaster
In the summer of 1976, a medicinal soap factory in the tiny northern township of Seveso, Italy, spewed a huge cloud of chemicals containing dioxin traces over 5 Italian towns. When a reaction container’s safety valve ruptured from the pressure of hot trichlorophenol, 736 persons living in the area of highest contamination evacuated their homes for over a year. An international medical team attended 4700 more from surrounding areas for the next decade.
Cleanup by plant owners and the Italian government took 8 years. Many homes were demolished and rebuilt outside boundaries of the contaminated zone. Bulldozers scraped up and removed tons of topsoil.
The accident changed the lives of people who worked at the plant or lived within the contaminated zone. The accident happened in the middle of the night and they knew nothing for 2 days. Then, their skin started burning. Many children developed blisters so severe they had to go to the hospital. Chickens and rabbits died, and the mayor warned citizens of the town not to even touch vegetables or fruits in their gardens.
Many left their homes while the chemical company cleaned the whole town. They abandoned their possessions since the poison covered everything. The doctors from the company advised pregnant women to have abortions because they feared the babies would be damaged.
For seven years after the accident, fertility rates for those suffering high exposure, dropped dramatically, and twice as many girls were born to those parents who did conceive. Between 1977 and 1984, of 74 children born of parents within closest range of the plant, 48 were female when, statistically, only 34 should have been. Parents with the highest chemical blood levels produced no male children at all. During this period some women produced girls, even when, in the father’s family, boys were the rule.
Testicular Dysgenesis Syndrome and EDCs
The Seveso incident, obviously, is an extreme example, but it glaringly demonstrates what goes on at a upper level while suggesting concerns for reduced exposure. The consequences of chemical exposure at a lower level sometimes seems to follow a U-shaped function with highest levels and lowest levels having greater effects than moderate ones, while others appear to be dose-dependent with higher doses having more effects than lower doses.EDC exposure, at various levels depending on the chemical, may allow male genitalia to form but disrupt its design. While this is difficult to measure in humans because exposure is typically undocumented, high quality controlled studies in animals clearly show a connection with EDCs for hydrospadias, cryptorchidism, adult prostate cancer, anomalies of the epididymis, seminal vesicles, vas deferens, altered germ cells, and reduced sperm concentration and motility. Testicular dysgenesis syndrome appears to have its roots in the anti-androgenic role of EDCs like phthalates and pesticides. [4][5] Some male reproductive/sexual disorders appear at birth, others surface at puberty and, still others, like prostate cancer, later in adult life.
These concerns should stimulate our society and the world in general to rebel against the present out-of-control chemical toxin production and use. Our money gives us the power to make changes in our environment. If we refuse to purchase toxin-containing materials, the chemical and pharmaceutical companies will respond by providing us with safer products we will buy. Our governments don’t even come close to providing safety from toxic materials either in industry, the work place, or in everyday life. Many of the EDCs to which we are regularly exposed have been grandfathered in “as safe” with no testing or evaluation by regulators. With all the scientific research accumulated on the destructive effects of EDCs, it seems unconscionable that authorities allow these activities to continue. To date, only a few EDCs have been banned and even then, for some, existing supplies can remain in use.
Common EDCs in Our Lives
An endocrine disruptor is defined as “an exogenous chemical, or mixture of chemicals, that interferes with any aspect of hormone action.” Examples of endocrine disruptors and their sources include, but are certainly not limited to:- Chlorotriazines– herbicides used on farms, parks, golf courses
- Benzenes – solvents, sealants, laundry starch, scatter rugs, bathmats, lubricating oil, automotive
- Phthalates (plasticizers) – soft plastics
- BPA, BPS, BPF – plastics, canned foods and drinks, packaging
- PCBs - fire resistant coatings, plastics, electrical transformers/equipment
- Dioxins – released from chlorine processing and products, plastics, burning of chlorine products, chemical plants, transformers, bleaching
- Benzo(a)pyrene – cigarette smoke, coal tar, auto exhaust
- Pyrethrins and Permethrin – pesticides, flea and tick treatment for pets
- PBBs - background exposure
- Many solvents – cleaning products, lubrication
- Phenols - detergents, pesticides, spermicides, cosmetics, plastics, soaps, surfactants, latex paint, lubricating oils
- Styrenes - plastic production, floor waxes, polish, paints, putty, cleaners, varnish, tobacco smoke, automotive exhaust, food containers
- Furans - used to dissolve glues and plastics, paints, varnishes, textiles
- Metals like lead, cadmium, and mercury – paint, batteries, pigments, electroplating, mining, welding, electronics, dental, laboratory, furnaces, metal recovery, agriculture, production of chlorine and fluorescent lighting, temperature devices, fish including shark, king mackerel, swordfish and tilefish.
- Unfiltered tap water – can contain estrogen from excreted medically prescribed hormones, pesticides, and multiple other EDs