High-Glycemic Foods May Fuel Addictive Cravings

By Joel Fuhrman, www.drfuhrman.com
September 3, 2015 Updated: September 3, 2015

For most people, hunger is not the only factor that influences eating behaviors, and some have more difficulty regulating their food intake than others. Scientists have proposed the excessively sweet, salty, and/or fatty (“highly palatable”) foods common in the standard American diet can produce addiction-like effects in the human brain, driving loss of self-control, overeating, and weight gain. In fact, the behavioral and neurobiochemical characteristics of substance abuse and overeating are quite similar, and the idea of food addiction is becoming more widely accepted among scientists.

Dopamine is a brain chemical that is involved in motivation, pleasure and reward. The dopamine reward system has been shown to be involved in overeating behaviors in animals, and the effects are similar to those of drug dependence. Studies on brain activity in humans have provided preliminary evidence supporting the idea that overeating alters the dopamine reward system, which then acts to drive further overeating. Substance abuse is known to reduce the numbers of dopamine receptors (called D2 receptors) in the brain, and this is thought to underlie the tolerance associated with addiction — over time, greater amounts of the substance are required to reach the same level of reward because the reward response has been reduced. Similarly, in the context of food addiction, reduced numbers of dopamine D2 receptors have been reported in obese compared to lean humans, and the dopamine reward response becomes diminished over a period of weight gain. The dopamine reward response is also reduced among women with bulimia compared to healthy women. Frequent consumption of ice cream was shown to reduce the reward response in adolescents. Together, these studies imply that overeating results in a diminished dopamine reward response, resulting in a constant cycle of overeating and a progressively worsening addiction to low-nutrient, highly palatable foods.

Tourists eat ice creams in central Rome on June 30, 2015 as a major heatwave spreads up through Europe, with temperatures hitting nearly 40 degrees.  AFP PHOTO / GABRIEL BOUYS        (Photo credit should read GABRIEL BOUYS/AFP/Getty Images)
The studies imply that overeating results in a diminished dopamine reward response, resulting in a constant cycle of overeating. Frequent consumption of ice cream was shown to reduce the reward response in adolescents. (Gabriel Bouys/AFP/Getty Images)

One new study investigated the relationship between the intensity of the blood glucose response to a certain food and the degree of activity in a reward-related region of the brain. Overweight and obese men were given either a high-glycemic index (GI) or low-GI shake (identical in number of calories and macronutrient distribution), and cerebral blood flow was measured four hours after the meal. The high-GI meal resulted in higher ratings of hunger and greater activation of the right nucleus accumbens, an brain region involved in pleasure, dopamine reward, and addiction. This study implies that the size of the blood glucose spike produced by a food correlates to the size of the addictive drive it produces in the brain.

This study provides more support for avoiding refined, high-glycemic foods, such as sugars, white flour products and white rice, because foods with a high glycemic load can promote cravings, possibly in part via the dopamine reward system, especially in those suffering with food addiction and struggling to lose weight. Whereas beans’ low glycemic load promotes satiety, and according to this new research, would reduce the potential for activating reward centers and producing addictive cravings making them the preferred carbohydrate choice.

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