A compelling study was published in the Pharmacognosy Magazine titled, “Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence.“ The study adds experimental support to concerns that fluoride is indeed a brain-damaging substance, also revealing that a natural agent derived from turmeric can protect against health effects associated with this compound is available.
The study was authored by researchers from the Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India, who have spent the past decade investigating the mechanisms through which fluoride induces severe neurodegenerative changes in the mammalian brain, particularly in cells of the hippocampus and cerebral cortex.
While the study focuses on negative effects of fluoride, it also cites evidence from other studies that point to benefits of fluoride use in appropriate amounts, including benefits for teeth and bones. To achieve these benefits, it is important fluoride isn’t over-ingested. Otherwise it can damage teeth and make bones more brittle.
The current study focused on fluoride-induced neurotoxicity and a process that leads to neuron death called excitotoxicity, which happens when overactive neurotransmitters damage or neurons (brain cells). The study identifies excitotoxicity and oxidative stress as the two main drivers of neurodegeneration, or the damage and death of our neurons. People with the condition known as fluorosis, a mottling of tooth enamel caused by excessive exposure to fluoride during tooth development, have been found to also have neurodegenerative changes associated with a form of oxidative stress known as lipid peroxidation (rancidity).
Lipids are one of the main components of cells. Lipid peroxidation is oxidative damage. It happens when free radicals take electrons from certain lipids called phospholipids that make up cell membranes. This process damages the cell.
Excess lipid peroxidation in the brain can lead to a decrease in total brain phospholipid content. Owing to these well-known mechanisms of fluoride-associated neurotoxicity and neurodegeneration, the researchers identified the primary polyphenol in the spice turmeric—known as curcumin—as an ideal agent worth testing as a neuroprotective substance. In short, they wanted to know if curcumin could protect our brains from damage that happens due to excessive levels of fluoride.
Previous research on curcumin indicates that it is capable of acting as an antioxidant in three distinct ways by protecting against 1) singlet oxygen, 2) hydroxyl radicals, and 3) superoxide radical damage. Also, curcumin appears to raise endogenous glutathione production in the brain, a major antioxidant defense system.
In order to assess the neurotoxic effects of fluoride and prove curcumin’s protective role against it, researchers randomly divided up mice into four groups for 30 days:
- Control (no fluoride)
- Fluoride (120 ppm): fluoride was given in distilled water drinking water without restriction.
- Fluoride (120 ppm/30 mg/kg body weight) plus Curcumin: Oral dose of curcumin dissolved in olive oil along with fluoride in drinking water
- Curcumin: (30 mg/kg body weight)
As was expected, the fluoride (F) only treatment group showed significantly elevated MDA levels vs. the non-fluoride treated control. The fluoride plus curcumin group saw reduced MDA levels versus the fluoride-only group, demonstrating curcumin’s neuroprotective activity against fluoride associated neurotoxicity.
The researchers concluded, “Our study thus demonstrate that daily single dose of 120 ppm fluoride resulted in highly significant increases in the LPO [lipid peroxidation, i.e. brain rancidity] as well as neurodegenerative changes in neuron cell bodies of selected hippocampal regions. Supplementation with curcumin significantly reduced the toxic effect of fluoride to near normal level by augmenting the antioxidant defense through its scavenging property and provides evidence of having a therapeutic role against oxidative stress mediated neurodegeneration.”
Discussion
This is far from the first study to demonstrate curcumin’s remarkable brain-saving properties. From the perspective of the primary research alone, there are more than 200 peer-reviewed published studies indicating that curcumin is a neuroprotective agent. On GreenMedInfo’s turmeric database there are 115 articles proving turmeric protects the brain. There are also two featured studies on turmeric’s ability to protect and restore the brain: How Turmeric Can Save the Aging Brain From Dementia and Premature Death, and Turmeric Produces ‘Remarkable’ Recovery in Alzheimer’s Patients.Considering the many chemical insults we face on a daily basis in the post-industrial world, turmeric may very well be the world’s most important herb, with more than 800 evidence-based health applications. Visit GreenMedInfo’s Turmeric Research database—the world’s largest, open access turmeric resource of its kind—to view the first hand published research on the topic.
The GMI Research Group is dedicated to investigating the most important health and environmental issues of the day. Special emphasis will be placed on environmental health. Our focused and deep research will explore the many ways in which the present condition of the human body directly reflects the true state of the ambient environment. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Sign up for the newsletter.
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