Immunotherapy is different from radiation or chemotherapy. Instead of directly killing cancer cells, immunotherapy tells the immune system to act in certain ways by stimulating T cells to attack the disease. Several different types exist or are in development, including pills called “checkpoint inhibitors” and CAR T cell therapy that involves removing a patient’s own immune cells and altering them genetically to seek and destroy cancer cells.
The problem, however, is that immunotherapy can cause the immune system to over- or under-react, Kim says. In addition, cancer cells are evasive and can hide from killer T cells. Aggressive tumors also suppress the immune system in the areas surrounding the malignancy (called the microenvironment), keeping T cells out.
- A biological study to understand and develop light-sensitive molecules that could efficiently guide T cells toward tumors. They discovered that a molecule called channelrhodopsin (CatCh), which is active in algae and is light sensitive, could be introduced to the immune system via a virus and activated to control the T cell response to cancer.
- An engineering study to invent an LED chip to test in mice.
The optical control was sufficient to allow the immune system to nearly wipe out the melanoma with no toxic side effects, the study reports.
Future studies, Kim says, would determine whether the wireless LED signal can deliver light to a tumor deep within the body instead of on the surface area and still have the ability to stimulate T cells to attack.
Immunotherapy for cancer is a hot area of research, as scientists try to improve success rates. Currently less than 40 percent of patients who receive immunotherapy get good results, although those who do respond are often dramatically better.
Kim emphasizes that his discovery is meant to be combined with immunotherapy to make it safer, more effective, and traceable. With improvements, Kim says, the optical method might allow doctors to see, in real time, if the cancer therapy is reaching its target. Currently when a patient receives immunotherapy, he or she must wait for several weeks and then undergo imaging scans to find out if the treatment worked.
“The beauty of our approach is that it’s highly flexible, nontoxic, and focused on activating T cells to do their jobs,” Kim said.
UR Ventures, the university’s technology transfer office, has filed for patent protection on the invention.
The National Institutes of Health funded the research.
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