Is Your Sandwich Hurting Your Brain?

By Rezzan Huseyin
Rezzan Huseyin
Rezzan Huseyin
October 5, 2015 Updated: October 5, 2015

Sorry if the image made you want a sandwich. Not helpful. 

This is an article about how regularly eating bread and other grain products affects your health, specifically the functioning of your brain. 

It could equally have been named, Is Your High Carbohydrate Diet Making You Stupid?, but that would’ve only been half of the story. 

It appears that our dietary over-reliance on bread and other gluten-containing grains (think wheat, barley, rye and spelt) has been doing us a mischief. 

And it’s not just that grains are a source of unnecessary carbohydrate – it appears that grain foods serve up a double-pronged inflammation attack on your intellect. 

So how exactly is the humble loaf of bread, once thought to be a healthy addition to diet, damaging our most prized organ? And how can we eat and live in a way that reduces our chances of developing cognitive decline conditions, and keeps us increasingly sharp? 

Documentary maker, Max Lugavere, who has been hanging out with the world’s top doctors and experts in neurological health, has a thing or two to say on the subject. I interview Max about his upcoming movie, Bread Head, below. 

But before we get to that, some background on how and why grain has fallen from grace so epically. 

When Carbs Became the New Fat

The demonization of whole food groups is nothing new (


The demonization of whole food groups is nothing new, and we should be cautious before making diet changes based on them. Dr Atkins, with his low carb, high animal fat diet, illustrated that. Even before carbs became a five letter dirty word, it was fat that was originally ostracized. We now know that that got us all into a hot mess with our health.

Although Atkins didn’t get the low carb diet quite right, the central premise – that carbohydrates make us fat – has stood the test of time. Research has demonstrated that low carbohydrate diets are more effective for weight management and many other markers of health. 

  • A diet that is relativity low in sugar, and higher in protein and healthy fats, is optimal for health;
  • The carbohydrates that we do eat should be ‘slow release’; and
  • Grains in their modern, heavily processed forms, have no place in a healthy diet.

The Grain Outliers 

Once understood to be pillars of a healthy diet, grains have come under nuclear scale attack in recent years. 

First up we had Wheat Belly author, Cardiologist Dr William Davis, exposing ‘healthy wholegrains’ as genetically altered Frankenwheat imposed on the public by agricultural geneticists and agribusiness. That opened up a few eyes and ears. 

More recently, neurologist David Perlmutter MD whipped up a storm in his bestselling book, Grain Brain

Perlmutter delivered the message that challenging brain problems, including Alzheimer’s disease, other forms of dementia, depression and ADHD, may be prevented with lifestyle changes. And what are those? A low carbohydrate and gluten free diet, coupled with higher fat and aerobic exercise. 

Perlmutter posited that: “It has become clear that gluten (a protein found in wheat, barley, and rye) and a high-carbohydrate diet are among the most prominent stimulators of brain-based inflammation.”

Grains – a Double Negative

In order of grain villainy, the heavily processed ones are the worst. (


Bread and other grain products send our blood sugar skyrocketing

Evidence suggests that the damaging effects of eating gluten-containing grains are twofold:

  1. The inflammatory reaction caused by ingesting gluten. Gluten sensitivity has been linked to a variety of neurological problems. Even if you have no demonstrable symptoms (or aren’t aware of them, or haven’t made the link between them and your bread habit), research shows that almost everyone has an immune response to gluten
  2. The effect of the astronomical content of sugar. Arguably the bigger issue, bread and other grain products send our blood sugar skyrocketing. So everything you have ever read about why sugar is bad for you applies to your baguette. And your wrap, and your panini. And pasta! Yep, even the wholegrain versions. 

1. The Deal With Glue-ten

Gluten is the primary protein found in grains like wheat, barley, rye and oats. Because it’s tricky to break down, gluten enters the small intestine undigested, where it causes intestinal irritation. This inflammation is disastrous to health. 

Are all grains created equal?

In addition to rice (brown, white, red and wild), better grains are amaranth, buckwheat, millet, quinoa, sorghum and teff. (


In short, no. But not in the way you might think.

The whole ‘brown’s better than white’ is part of that same old paradigm that pedaled fat as being unhealthy for us.

This is not the part where I tell you that wholegrains are healthy. The whole ‘brown’s better than white’ is part of that same old paradigm that pedaled fat as being unhealthy for us. 

Brown bread is probably an even heavier contender for our dustbins than its white counterpart, purely because we have been indoctrinated to think that it’s good for us. 

In order of grain villainy, the heavily processed ones are the worst. Dr Perlmutter says it is clear that “structurally modified, hybridized grains contain gluten that’s less tolerable than the gluten that was found in grains cultivated just a few decades ago.” 

Dr Mark Hyman, author of The Blood Sugar Solution, agrees: “This new modern wheat may look like wheat, but it is different in three important ways that all drive obesity, diabetes, heart disease, cancer, dementia and more. It contains a super starch, amylopectin A, that is super fattening, a form of super gluten that is super inflammatory, and [acts like] a super drug that is super addictive and makes you crave and eat more.”

There are healthier grains, though. And despite their high carbohydrate content, some of us may still want to include them in our diets (we will look at why below). In addition to rice (brown, white, red and wild), better grains are amaranth, buckwheat, millet, quinoa, sorghum and teffThere are more too

2. Why Bread Ought to Taste Sweet 

Most grain foods are 70% carbohydrate (that is, 70 grams of carbohydrate per 100 grams). That’s sugar. Your blood doesn’t know the difference. 

Here is a label from an organic spelt product (spelt is wheat and contains gluten).



You’ll see that of a serving size of 1 cup (174 grams), 124 grams is sugar. 

Every time we eat sugar that we don’t burn off, we form AGEs (Advanced Glycaemic End Products), which is one of the major causes of early onset ageing and degenerative disease (see my previous article on ageing). Your brain suffers in a particular way when you eat sugar, which I explain more below. 

The Grain – Brain Connection 

Bread grain

Research shows that when we eat grains, our brain function decreases, we can develop brain damage over time and our IQ can even lose a few points. It’s understood that we have lost 10% of our brain mass since the dawn of agriculture.

1.  Your Brain on Gluten

Here’s a mind-blowing idea: a gluten intolerance can manifest exclusively in your brain. So that’s gluten intolerance without any gastrointestinal problems whatsoever. Scary stuff. 

Dr Maios Hadjivassiliou of the UK, a recognized world authority on gluten sensitivity, has reported that “gluten sensitivity can be primarily and at times, exclusively a neurological disease.”

Here are two specific ways that eating grains appears to damage the brain:

Inflammation: Gluten causes leakiness of the blood-brain barrier, resulting in inflammation. Chronic inflammation is a factor in early onset degenerative disease, including cognitive decline. Perlmutter has said that “All of the neurodegenerative diseases are really predicated on inflammation.” 

We develop toxic antibodies: It is understood that we form specific antibodies to gluten molecules. The formation of one of these antibodies, GAD, is implicated in type I diabetes, adult auto-immune diabetes and Parkinson’s disease. The main neurological disorder believed to be at least partly caused by gluten is a disease that involves an inability to coordinate balance and problems talking. I know – sounds like you on a Friday night. 

2. Excess Carbohydrates and Your Brain 



Most of us already knew that too much sugar helps to make us fat and give us bad skin. 

Well, excessive carbohydrates are awful for the brain too, affecting long term cognitive function and short term psychological wellbeing. 

Endocrinologist Dr Medha Munshi has said research “offers more evidence that the brain is a target organ for damage by high blood sugar.”

Here are some specific ways that a diet that is excessively high in carbohydrates has been linked to brain detriments:

It causes inflammation: Inflammation in the brain causes neurons to fire more slowly, slowing down mental acuity, recall, and reflexes. High inflammation eventually results in chronic disease.

Resistance to insulin: Insulin, the hormone that controls blood sugar levels, regulates the function of brain cells, too. Insulin strengthens the synaptic connections between brain cells, helping them to communicate better and thereby form stronger memories. So when insulin levels in the brain are lowered as the result of excess sugar consumption, cognition can be impaired.

Affects our learning and memory: Prorogued high blood sugar levels affects the production of a chemical known as brain-derived neurotrophic factor (BDNF). Without BDNF, our brains can’t form new memories and we can’t learn or remember much of anything. 

Alzheimer’s – Type 3 Diabetes 

Neuroscientist, Suzanne de la Monte MD, was the one to coin the term. 

Brain cells use glucose as fuel, and insulin instructs the cells to mop up glucose in the blood. De la Monte’s big insight was that brain cells can develop insulin resistance, just like other cells in the body.

Any organ can be affected by insulin resistance. You can have it in the liver – we call that non-alcoholic fatty liver disease. If you get it in the kidney, we call it renal disease. If you get it in the brain, we call it Alzheimer’s.
— Neuroscientist, Suzanne de la Monte MD

“Any organ can be affected by insulin resistance,” de la Monte says. “You can have it in the liver – we call that non-alcoholic fatty liver disease. If you get it in the kidney, we call it renal disease. If you get it in the brain, we call it Alzheimer’s.” 

Her research has revealed that this creates a toxic environment for the brain, leading to the harmful buildup of proteins and neuron death seen in Alzheimer’s.

In addition to telling us more about how Alzheimer’s can be prevented through healthy diet and exercise, her insights could also help potentially treat the disease. 

Max Lugavere interviews Suzanne as part of his documentary.