Childhood Obesity Could Increase the Risk of Multiple Sclerosis in Later Life

While smoking has fallen as a risk factor, a rise in childhood obesity looks set to increase as a factor in MS rates
September 7, 2020 Updated: September 7, 2020

Obesity and smoking are well-known risk factors for heart disease and cancer. What is less well known is that they’re associated with an increased risk of multiple sclerosis (MS).

Several studies looking at how MS develops have associated childhood obesity and smoking with a significant increase in the subsequent risk of getting the disease. MS is becoming increasingly common, and changing rates of childhood obesity and smoking may be contributing to this.

Studying the link between behavior or events in childhood and later-life development of MS is complex. MS is an auto-immune disease of the central nervous system that affects about one in every 500 people. This means that a large number of people need to be studied from a young age to get an accurate picture of the effect of changes in behavior or lifestyle on the risk of MS in adulthood.

While we know from earlier studies that childhood obesity increases the risk of MS, the findings don’t clearly show how changing patterns of childhood obesity in the population might affect the frequency of MS in the future. To better understand this, our research looked at the proportion of MS risk that could be attributed to obesity and smoking. The results of our analysis are published in the International Journal of Epidemiology.

What Is Already Known

Many studies have looked at the relationship between smoking and MS. The largest of these included more than 590,000 people from around the world. It showed that smokers are around 50 percent more likely to develop MS than non-smokers.

Studying the relationship between adolescent obesity and MS is more complicated—few studies have weighed people in childhood and then followed enough people over the years to see if they develop MS. A study looking at the association between genes associated with childhood obesity and MS showed that people who are obese as children have a 20 percent increased risk of MS—a similar result to that seen in smaller studies that measured weight in childhood and followed people up into adulthood.

These results can be used alongside information about the frequency of smoking and obesity in the entire population of a country, to calculate how much these factors contribute to MS risk in that country. As there is a time lag between childhood obesity, starting smoking, and future MS development, we used current information to estimate how this might change in the future.

Smoking, Obesity, and MS

We found that smoking was responsible for between 10 and 14 percent of the population risk of MS in the United Kingdom, United States, Russia, and Australia in 2015. This is much higher in Russian males (22 percent), reflecting high rates of smoking. By 2025, the population risk attributable to smoking is projected to decrease in all the countries studied to between 7 percent and 12 percent.

In the United States, childhood obesity accounted for a higher proportion of 2015 MS risk than smoking. Childhood obesity in the United States in 2005 accounted for an eventual 11 percent of MS risk in 2015. In the United Kingdom, this figure was 8 percent. Worryingly, when the potential impact of 2015 rates of childhood obesity are projected, this will contribute up to 14 percent MS risk in the United States and 10 percent in the United Kingdom in 2035.

Trying to look at the combined effects of smoking and obesity is more complex, as the current evidence doesn’t tell us the amount of overlap between the two factors. The overall effect is likely to remain roughly stable, as the increase in childhood obesity offset reductions in smoking.

While this research can’t tell us how childhood obesity and smoking increase MS risk, it shows that there is an urgent need to address childhood obesity. Increasing rates of childhood obesity mean that any gains in MS prevention caused by reduced levels of smoking will be lost. While cancer and heart disease occur in later adulthood, MS onset in young adulthood may be of greater concern to younger people.

Reducing childhood obesity and smoking is likely to have an important impact on MS incidence. Our work shows the size of the problem and highlights the need to act urgently.

 is a clinical senior lecturer in neurology and honorary consultant neurologist at Queen Mary University of London in the UK. This article was originally published on The Conversation.