US, Partners Launch New Strikes on ISIS Targets in Syria

The strikes are part of a continuing bombing campaign in response to a Dec. 13 ISIS attack that killed two U.S. troops and a civilian interpreter.

A U.S. Air Force A-10 Thunderbolt II takes off from a base in the U.S. Central Command area of responsibility in support of Operation Hawkeye Strike, on Jan. 10, 2026. U.S. Air Force

U.S. and partner forces conducted a series of airstrikes on ISIS targets throughout Syria on Jan. 10, the U.S. Central Command (CENTCOM) announced.

The series of airstrikes on the ISIS terrorist group began at about 12:30 p.m. EST, CENTCOM said in a statement several hours after the strikes.

“The strikes today targeted ISIS throughout Syria as part of our ongoing commitment to root out Islamic terrorism against our warfighters, prevent future attacks, and protect American and partner forces in the region,” the statement reads. “U.S. and coalition forces remain resolute in pursuing terrorists who seek to harm the United States.

Footage shared by CENTCOM showed F-15 and A-10 aircraft taking off from an unspecified location and showed strikes on purported targets.

CENTCOM did not specify which partner forces assisted in the Jan. 10 strikes throughout Syria.

The Jan. 10 strikes are part of a continuing retaliatory bombing that began after two U.S. soldiers and a U.S. civilian interpreter were killed in an ambush attack in Palmyra, Syria, on Dec. 13, 2025. Three more American troops were injured in the attack.

ISIS claimed ultimate responsibility for the Dec. 13 shooting, and Syria’s Interior Ministry has said the suspect was a member of Syrian security forces who harbored ISIS sympathies. Syria’s Interior Ministry said it had arrested five more suspects in connection with the Dec. 13 attack.

Since sweeping into Damascus and driving off then-Syrian President Bashar al-Assad in December of 2024, Syria’s de facto interim government has been largely composed of Sunni Islamist militants from Hay'at Tahrir al-Sham, which began as a Syrian branch of the al-Qaeda terrorist group.

The U.S. bombing campaign, known as Operation Hawkeye Strike, began on Dec. 19, 2025, when U.S. and Jordanian forces employed dozens of fighter aircraft, attack helicopters, and artillery pieces firing more than 100 munitions and struck more than 70 ISIS targets across central Syria.

Between Dec. 20 and Dec. 29, U.S. and partner forces conducted 11 more missions under Operation Hawkeye Strike, in which they reported killing seven ISIS suspects and capturing several others.

“Our message remains strong: if you harm our warfighters, we will find you and kill you anywhere in the world, no matter how hard you try to evade justice,” CENTCOM’s Jan. 10 statement reads.

The U.S. military officially began striking ISIS targets in Syria in 2014 and has maintained a continuing troop presence within the country for the past decade. This counter-ISIS mission has coincided with the Syrian civil war, as Assad fought to retain power until rebel forces drove him out in December 2024.

Reuters contributed to this report.