Paramedics said a man in his 50s and three men in their 30s were pronounced dead at the scene, while a woman evacuated in critical condition to Shaare Zedek Hospital was later declared dead.
Prime Minister Benjamin Netanyahu is holding an emergency assessment with the heads of Israel’s security establishment in the wake of the attack.
The casualties include seven people in serious condition with gunshot wounds, two in moderate condition, and three lightly injured by glass fragments, according to Israel’s ambulance service, Magen David Adom (MDA).
Victims were evacuated to Jerusalem’s Shaare Zedek, Hadassah Ein Kerem, and Hadassah Mount Scopus hospitals. MDA said it supplied roughly 60 units of blood and blood components to support life-saving treatment for the injured.
Security forces were deployed in large numbers to the area following the attack.
The Israeli military said that, for the second time on Sept. 8, sirens were sounded in southern Israel following the infiltration of a hostile aircraft.
Hamas, which carried out the Oct. 7, 2023, attack on Israel that killed 1,200 people and resulted in 251 abductions, hailed the latest assault without claiming responsibility, calling it a “natural response to the occupation’s crimes against our people.”