Kick off is 2:30 p.m. ET (8:30 p.m. CET) at Wörthersee Stadion.
The game will be broadcast live on ORF 1 in Austria, and VTV Uruguay in Uruguay.
The game will also air on beIN Sports USA in the United States.
Live stream is available on beIN Sports Play.
Although key player Edinson Cavani is out injured, Uruguay, with the likes of mercurial Liverpool forward Luis Suarez and 2010 World Cup Golden Ball winner Diego Forlan, are clear favorites to take this tie.