The crash involved two Philadelphia Police cruisers at 10 a.m. local time in the Kensington area of the city.
Footage shows a police SUV with serious front-end damage. Another SUV was up on the sidewalk with side damage, and that vehicle appears to have struck a utility pole and a building.
Two officers were in each SUV, and all of them were hospitalized and listed in stable condition.
The cars crashed while they were responding to a shooting at C Street and Allegheny, according to 6ABC.
An eyewitness said one of the SUVs was traveling in the wrong direction at the time of the accident.
Transit police arrested a suspect in the shooting near Kensington and East Allegheny avenues. No victim was found in the shooting, the CBS affiliate reported.