The town of Warrington starts the highest level of COVID-19 measures from midnight, with 200,000 people joining the 7.1 million already under Tier 3 in the north of England.
The council said an uptick in infections had pushed them to accelerate plans by two days, with the original plan to introduce restrictions on Thursday.
"The upsetting and grim reality is that there are more people in hospital, more people in intensive care beds and more people being taken by the virus, and we need to do all we can to try to bring this under control."
Announcing the new measures, the council said it had secured a £5.9 million support package, with £4.2 million earmarked to support businesses.
The decision was made jointly by the central government and the Warrington council. The measures, which come into force at 00:01 a.m. on Tuesday, are to be reviewed in 28 days.
According to the Department of Health and Social Care, infection rates in the town are among the highest in the country at 361 cases per 100,000.
The four other regions already under Tier 3 restrictions, which also correspond to the highest infection rates, are all in the north: South Yorkshire, Liverpool, Greater Manchester, and Lancashire.
Tier 3 restrictions include a ban on pubs opening unless they are serving meals.
The three-tier approach is unique to England.
Wales on Friday entered what it's calling a "firebreak" lockdown, with people asked to stay at home "except for very limited purposes", for two weeks.
He said that the measures were to “reset the clock and allow us to get through to Christmas”.
“We’re meeting retailers this afternoon to review the regulations and guidance to make sure that it is being applied fairly and consistently,” he told reporters. “If there are anomalies, we will look at whether the guidance needs to be revised or strengthened to make it clear that supermarkets have some discretion to sell to people who are in genuine need.”