NFL Week 6 Injury Roundup: Anthony Richardson, Garrett Wilson, Fred Warner Among Those Wounded

From a pair of bizarre pregame injuries to Colts players, to a trio of former Ohio State wideouts going down, NFL Week 6 was a brutal one.

Anthony Richardson of the Indianapolis Colts warms up prior prior to the game against the Las Vegas Raiders at Lucas Oil Stadium in Indianapolis, Ind., on Oct. 5, 2025. Michael Hickey/Getty Images

With a collision sport like pro football, there’s no denying that every NFL week is littered with injuries. However, Week 6 was particularly brutal around the league, with both some of the biggest names going down, as well as some of the most unique injuries you’ll ever come across.

Here are the most notable Week 6 NFL injuries, starting with ones that happened pregame in Indianapolis.

QB Anthony Richardson, Colts

While warming up with a resistance band in the locker room, the band, or the apparatus it was attached to, somehow malfunctioned. That led to it snapping back into Richardson’s face, injuring his eye, and fracturing his orbital bone. The injury was so bad that it forced Richardson to go to the hospital, thus missing Indy’s home game versus Arizona, and the mishap will leave him unavailable for multiple weeks.

Much of Richardson’s lack of NFL success has been to his own doing, but this was simply poor luck for the quarterback. In his place, rookie Riley Leonard, will serve as starter Daniel Jones’ backup.

CB Charvarius Ward, Colts

If it wasn’t for Richardson, then his teammate Ward would have had the strangest injury of the day. During pregame warmups—this time on the field instead of in the Colts locker room—Ward was sustained a concussion when he collided with teammate Drew Ogletree. Ward was backpedaling during a drill, on one part of the field, while Ogletree appeared to be running a route about 15 yards away. However, the two didn’t see each other and ended up crashing into one another.

Ward is 6-foot-1 and 196 pounds, while Ogletree is 6-foot-5 and 260 pounds, so, almost needless to say, you can guess who took the worse of the collision. Ogletree wasn’t even knocked off his feet, while Ward immediately went down to the turf, was diagnosed with a concussion, and missed his first game of the year.

3 Former Buckeyes Wideouts Go Down

Ohio State has a claim of being called WRU, due to the number of standout wide receivers it has sent to the NFL. But a trio of them could end up missing time due to injuries on Sunday.

The first took place across the pond in London when Garrett Wilson of the Jets hyperextended his knee, which will sideline him a couple of weeks. Wilson has never missed a game in his four-year NFL career, and now the NFL’s only winless team will have to manage without a monumental cog in its passing game. Wilson’s 395 receiving yards not only top the Jets, but they are twice as many yards as every other Jets wideout has combined (183 yards).

Meanwhile, Indianapolis was a House of Horrors on Sunday as it was the scene of another injury, this time on the opponent Cardinals. Playing in the place where his dad’s jersey hangs from the rafters, Marvin Harrison Jr. banged his head on the turf while being tackled in the second quarter, left the game, and did not return. He was diagnosed with a concussion, which is his second known one after also having one last season. He didn’t miss a game after last season’s, which coincidentally also occurred in Week 6, but now with multiple, it may be harder for him to pass through the league’s concussion protocol and suit up in Week 7.

The third former Buckeyes wide receiver to be sidelined was stud rookie, Emeka Egbuka, of the Buccaneers. Already without the team’s top two wideouts, Mike Evans and Chris Godwin, Egbuka tweaked his hamstring in the first half and did not return, finishing the game with two catches. Soft-tissue ailments like this are notoriously slow to heal and aren’t ones you want to rush back from. With Tampa having a bye in Week 9, there’s a good chance that Egbuka—a top contender for Offensive Rookie of the Year—won’t take the field again until Week 10.

LB Devin Lloyd, Jaguars

The NFL leader in interceptions with four, Lloyd, who injured his calf, left halfway through Sunday’s loss to Seattle and has already been ruled out for Week 7’s game versus the Rams. While teams normally wait until later in the week to divulge a player’s availability, the Jags play in London next week and flew to the city on Monday night, with Lloyd not on the flight.

WR Puka Nacua, Rams

Nacua is also in danger of missing the Rams vs. Jaguars London game after the NFL’s leading receiver logged just 27 snaps in Sunday’s win over the Ravens due to an injured ankle. However, coach Sean McVay labeled the ailment as “day-to-day” giving Rams, and Londoners, hope that he’ll suit up on Sunday. Even with just two catches versus Baltimore, Nacua is on pace for 153 receptions, which would break the single-season record of 149 by Michael Thomas in 2019.

LB Fred Warner, 49ers

The biggest Sunday injury—both in terms of seriousness and name recognition—occurred to future Hall of Famer, Fred Warner. A four-time first-team All-Pro, Warner suffered a dislocated and broken ankle in San Francisco’s loss to Tampa Bay, which will necessitate surgery and end his season. Warner has been akin to an Iron Man of sorts, having missed only one game over his first seven seasons, and even suiting up for every game last season despite dealing with another ankle injury.

Prior to this season, Warner signed an extension that made him the highest-paid linebacker in NFL history. But he isn’t content with just cashing a check, as just after his season-ending injury, the Southern California native channeled his inner Kobe Bryant. Warner shared Bryant’s famous social media posting after the NBA legend tore his Achilles’ tendon in 2013, with the linebacker vowing to return to the field. He ended the social media message with “now it’s time to inspire through the comeback I’m bout to have. It will be LEGENDARY and right on time God willing.”