Christian McCaffrey rushed for 116 yards on 20 carries and scored a touchdown to lead the San Francisco 49ers to a 30–23 win against the Los Angeles Rams on Sunday, September 17, afternoon at Inglewood, Calif.
San Francisco quarterback Brock Purdy completed 17 of 25 passes for 206 yards for the 49ers (2–0). He had no interceptions for the second consecutive game.