In what seems like an inevitable development, scientists Katalin Karikó and Drew Weissman have been awarded the 2023 Nobel Prize in Medicine for their role in developing the mRNA technology underlying the Pfizer-BioNTech and Moderna COVID-19 vaccines which were rolled out in late 2020.
“Their chief safety concerns, which they said should be closely watched in future trials, were about local and systemic inflammation, as well as keeping tabs on the ‘expressed immunogen’ and on any auto-reactive antibodies.”
“‘A possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity,’ they wrote. ‘Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken.’”
“The authors also noted that extracellular RNA could contribute to edema, and cited a study that showed it ‘promoted blood coagulation and pathological thrombus formation.’”The MedPageToday article is titled “Want to Know More About mRNA Before Your COVID Jab?” How many readers actually went ahead and got it after they knew? At least readers of the MedPageToday article cannot say they lacked informed consent.