Kate Moss and Topshop will end their three-year design relationship after showing their autumn/winter collection in October.
Topshop boss Sir Philip Green told The Times newspaper: “It has been fantastic for us and fantastic for her, but they take more and more time and she cannot do this full-time anymore because she has other commitments.
According to the contactmusic.com website, a source close to the British model said the relationship had come to a "natural conclusion.”
The upcoming collection will be her 14th at Topshop. She is believed to have earned £3 million from the venture.
She helped to open up the store's first New York outlet in 2009.
Kate fronts her own perfume range and is currently on the cover of British Vogue.
Sir Philip is helping the Government deliver efficiency savings in Whitehall.