Southern CaliforniaIrvine Named Best Large City in California for New BusinessesSaveMark Us Preferred on GooglePrintIrvine, Calif., John Fredricks/The Epoch TimesTim Shaler4/29/2021|Updated: 4/29/2021CommentaryIrvine, Calif. is the best large city in the state to open a new business, according to a new tabulation by financial website WalletHub.We had a problem loading this article. Please enable javascript or use a different browser. If the issue persists, please visit our help center.