The COVID-19 drug Paxlovid can have dangerous interactions with common medications used to treat cardiovascular disease, including certain statins, warned doctors in a new review paper.
A paper published Wednesday in the Journal of the American College of Cardiology shows the combination of nirmatrelvir and ritonavir, or Pfizer’s Paxlovid, can interact with a number of commonly prescribed cardiovascular medications. Ritonavir, first approved to treat HIV in 1996, impacts the CYP450 pathway that’s involved in metabolizing a number of medications—as well as the P-glycoprotein drug efflux pump, according to the paper.
