Cardinals Use Two Pick-6s in First Half to Down Saints 42–34

Kyler Murray (1) of the Arizona Cardinals passes during the 3rd quarter of the game against the New Orleans Saints at State Farm Stadium in Glendale, Ariz., on Oct. 20, 2022. Christian Petersen/Getty Images

GLENDALE, Ariz.—Marco Wilson and Isaiah Simmons scored touchdowns on two pick-6s late in the first half and used that stunning change in momentum to lift the Arizona Cardinals over the New Orleans Saints 42–34 on Thursday night, Oct. 20.

The Cardinals (3–4) snapped an eight-game home losing streak that was the franchise’s longest since 1958.