The antiviral remdesivir treatment reduced the risk of hospitalization among COVID-19 patients when administered soon after they were diagnosed, according to a new study from Gilead Sciences, which developed remdesivir.
Researchers found that remdesivir cut the risk of hospitalization by 87 percent compared to a placebo that half of the study participants received.
A total of 562 patients, all deemed at high-risk from COVID-19, were enrolled in the trial.
The Phase 3 study was a randomized, double-blind trial, but trial enrollment stopped in April because the company struggled to find enough participants. It continued to follow those who had enrolled, half of whom were given a placebo.
The new study showed a similar safety profile to the placebo and no deaths occurred in either group by the primary endpoint at day 28, though one person who was given the placebo died on day 59, Gilead said.
Competing Treatment OptionsParticipants received the antiviral through IV on three consecutive days as nonhospitalized patients. That’s impractical for people outside of hospitals, some experts say.
Chandy John Lab, professor of pediatrics at the Indiana University School of Medicine, wrote in a social media post that monoclonal antibodies are designed to prevent hospitalization and only require a single dose, making them a preferred treatment option over remdesivir. Both cost thousands of dollars.
Remdesivir has been touted by top U.S. officials in the past, including Dr. Anthony Fauci. But other research has suggested that it has no benefit, including a trial across 48 sites in Europe.