‘Significantly More’ Adverse Events in COVID-19 Trials Are From Vaccine Recipients Compared to Placebo: Study

‘Significantly More’ Adverse Events in COVID-19 Trials Are From Vaccine Recipients Compared to Placebo: Study
An investigational pharmacy technician holds a dose of the Johnson & Johnson COVID-19 vaccine before it is administered in a clinical trial in Aurora, Colorado, on Dec. 15, 2020. Michael Ciaglo/Getty Images
Updated:

Many reported adverse events in COVID-19 vaccine trials come from those who received the placebo shots, with nearly a third of placebo recipients involved having reported at least one adverse event, but “significantly more” adverse events were reported by those in the vaccine groups, according to researchers at Beth Israel Deaconess Medical Center, a teaching hospital of Harvard Medical School.

Adverse events (AEs) that appear to be induced by placebos are referred to as “nocebo” responses.