The explosion took place at the 4400 block of Cleveland Drive, near West Park Boulevard and Coit Road at around 4:45 p.m. local time, Plano Fire-Rescue confirmed to The Dallas Morning News.
The cause of the explosion is not yet determined, the fire department said.
Investigators from Atmos Energy were at the scene, according to multiple reports.
Photos of the area via local outlet KDFW showed the entire house demolished to a pile of rubble, with overflow debris seen on the street. There was also some damage to neighboring homes.
The area has been cordoned off for an investigation.
According to KTVT, the six people taken to the hospital included three adults and three children of whom at least one was from a neighboring house.
Their conditions and identities were not immediately known.
The outlet noted that sixteen fire and police units were at the scene, and gas was shut off to the area.
Plano Mayor John Muns asked the community to “keep the victims in your prayers,” the outlet reported.