Why do some people report adverse events after COVID-19 vaccinations while some do not? This question is central to the controversy of COVID-19 vaccine adverse events.
Doctors have identified several factors that contribute to an increased risk of spike protein-induced disease, specifically, post COVID-19 vaccine injury.
Dr. Paul Marik—Front Line COVID-19 Critical Care Alliance(FLCCC) co-founder—said at an FLCCC conference on Oct. 15 that there are many overlaps in the symptoms and disease mechanisms of long COVID and injury from the COVID-19 vaccines.
Both diseases are systemic, affecting multiple organs, tissues, and are both driven by a high load of spike protein. These spike proteins trigger inflammation, mitochondrial dysfunction, and autoimmunity.
However, not everyone will experience these symptoms.
Whether a person will suffer from spike protein injuries is dependent on factors that are both unchangeable and temporal.
Spike Protein Exposure Increases Risk, SeverityThe best way to reduce spike protein injuries is to reduce opportunities of spike protein exposure through infections or vaccinations.
While early treatment can usually prevent spike protein exposure by clearing spike from the lungs, blocking spike from entering the blood. Vaccines bypass the lungs by administering spike protein genetic materials directly into the muscles and blood vessels.
There is a dose-response with the vaccine, such that the greater the number of vaccine doses, the higher the risk of spike protein injury.
“The more the patients are exposed to spike [proteins], the more severe the disease,” said Marik.
Dr. Flavio Cadegianni hypothesized that receiving COVID-19 vaccines after having had COVID-19 increases one's risk of spike protein injury. This is because vaccines likely trigger a higher amount of spike protein load in the bloodstream than a common COVID-19 infection.
In a common COVID-19 infection, it is difficult for the virus to enter the bloodstream through the lungs, but the vaccination gives spike protein mRNA and DNA a one-way ticket into the deltoid and then into the bloodstream.
The mRNA and DNA vaccines then enter the blood vessels and endothelial cells, these cells then produce spike proteins and present them on their cellular surface, resulting in an immune attack against these cells.
Spike proteins from vaccines can also be free-floating in the bloodstream and in the extracellular fluid (lymph fluid). These spike proteins can trigger inflammatory pathways by binding to and reducing ACE2 receptors, forming complexes with antibodies, and triggering immune pathways that lead to pro-inflammatory responses.
Dr. Pierre Kory, co-founder of FLCCC, who now has a clinic for treating long COVID and vaccine injury, said that he noticed his patients with either of these conditions would appear to worsen with subsequent spike exposures.
He recommended his patients to therefore avoid opportunities that may lead to spike protein exposure lest their symptoms go out of control.
Varied Loads in VaccinesNot all vaccine vials are made equal.
By separating each adverse event into its corresponding vaccine batch, the website has shown that some vials are likely different from others, as they are associated with a greater number of adverse events, deaths, and disabilities.
This could be due to impurities in the vaccines.
However, potential issues could also be due to the dosage; some vials may have a higher mRNA or DNA spike protein content than others.
Currently, doctors have no way to verify what is in the vials.
Nass had her medical license suspended by the Board of Licensure in Medicine (BOLIM), a state agency that regulates medical licensing in Maine. In January 2022 she received an order to submit to a neuropsychological evaluation by a psychologist selected by BOLIM to determine whether she was competent to practice medicine, citing her online criticism of COVID-19 policies as cause for concern. She filed a lawsuit and recently had a hearing.
Genetic Factors“There's a genetic predisposition,” said Marik. “If someone in the family is vaccine injured, it is very common that the brothers of that individual … [will also become] vaccine injured so there are genetic factors which we don't understand.”
Marik has observed that certain genetic mutations may also put them at a greater risk of COVID-19 vaccine injury.
This included individuals with a methylenetetrahydrofolate reductase (MTHFR) gene mutation and those with Ehlers-Danlos type syndromes.
Depending on the type of the MTHFR mutation and the number of copies a person carries, the MTHFR enzyme function can be moderately or severely reduced.
This can put a person at a higher risk of folate deficiencies, which also increases a person's risk of severe COVID-19 such that homocysteine levels have been directly predictive for worsened COVID-19 outcomes.
Underlying Chronic Diseases and Immune DeficienciesMetabolic diseases, especially high blood pressure and type 2 diabetes, have been associated with severe symptoms in COVID-19 infections and vaccination.
Many metabolic diseases including obesity, diabetes, hypertension, and cardiovascular disease are driven by inflammation. The spike proteins also trigger many inflammatory pathways, which may be why people with these chronic diseases are at a greater risk.
Spike proteins both from the virus and the vaccine can bind to ACE2 receptors displayed on cells across any tissue it comes into contact with. ACE2 is responsible for reducing inflammation, but this binding reduces ACE2 receptors and therefore increases inflammation across the tissues.
“We’re talking about mononuclear cells in the brain, in the heart, in the liver, the spleen in the ovaries, so it results in a systemic disease,” said Marik.
Spike proteins are also highly autoimmune, meaning that it is able to trigger the immune system to mount attacks against self-tissues.
A significant finding Marik and Kory observed was that individuals suffering from vaccine injury have a higher concentration of autoantibodies than those with long COVID.
Those with a relapse of autoimmune diseases often experienced symptoms of greater severities.
These are all suggestive that people with underlying chronic diseases that compromise their health and immune system are at a greater risk of possible vaccine injury.
Vitamin DeficienciesDeficiencies in folate, cobalamin (vitamin B12), and vitamin D have been associated with an elevated risk of COVID-19 infection.
Vitamin D is anti-inflammatory and can boost immune action. Vitamin B12 is critical for neural health as it helps to produce myeline—a fatty coat wrapped around neurons that protects them from scarring and improves neural messaging.
"Vaccines, including the COVID-19 vaccines, are known to cause severe and/or chronic neurological reactions in rare cases. We support screening for vitamin B12 deficiency prior to vaccination in high-risk groups,” wrote the study authors.
Age and SexMarik said that women generally have a higher risk of suffering from symptoms following COVID-19 vaccination.
The survey found that 81 percent of people reporting vaccine injury were females. Between the two sexes, patients aged between 30 to 50 were the most prevalent.
Data from VAERS also showed that women constituted around 65 percent of the adverse event reports; 41 percent of these reports came from women aged 18 to 49 at the time of the report.
Women in the 50 to 59 age bracket and the 65 to 79 age bracket also constituted a large fraction of the adverse event reports, taking up almost 35 percent of all reports in females.
Spike proteins trigger inflammation through many pathways. One pathway is through binding to ACE2 receptors on cell surfaces. This receptor is important for reducing inflammation, and a reduction of ACE2 through spike protein interaction thus increases inflammation.
Since the rollout of vaccines, many women have reported menstrual irregularities.