Police have launched an investigation into his death, the spokesman said.
Magen David Adom paramedics told Israeli media that 57-year-old Du Wei was found dead lying in his bed. He appeared to have died in his sleep of natural causes.
The suspected cause of death is heart failure, Times of Israel reported.
Police did not immediately comment on the cause of death of Du, who became ambassador to Israel in February, according to the embassy’s website.
Before that, Du served as China’s ambassador to Ukraine.
He leaves behind a wife and son.
Reuters contributed to this report.