Millions Have It, but Chronic Pain Is Still a Mystery to Doctors
Millions Have It, but Chronic Pain Is Still a Mystery to Doctors

In all of medicine there may be no bigger mystery than chronic, nonmalignant pain—especially to those of us who treat it. Pain usually serves a biological purpose, yet in chronic pain patients, pain symptoms seem to exist with little biologically useful purpose.

We know that pain can be ignored by soldiers and others in crises. We know that pain that is considered debilitating in one culture can be barely acknowledged in another culture. The same pain event that becomes resolved in one patient can turn into chronic pain in another. Chronic pain can strangely exist in limbs that are amputated or paralyzed.

These ambiguities and even paradoxes in the experience of pain strain the physician-patient relationship as both parties become frustrated at the ability of chronic pain to confound treatment.

Clearly, pain is necessary to our survival. In rare cases, humans are born without the ability to encode and process harmful stimuli in the nervous system and endure dangerous consequences. Medical textbooks tell the story of “Miss C,” a Canadian girl who was born with a congenital insensitivity to pain.

Miss C “showed no physiological changes in response to noxious stimuli. Similarly, she never sneezed or coughed, she had an extremely weak gag reflex, and she had no corneal reflex. As a child, Miss C bit off the tip of her tongue and sustained third-degree burns from her inability to sense pain.

As an adult, she developed severe erosion and infection in her knees, hip, and spine from failing to shift her weight or turn over in bed.

It is also clear that pain perception can be “turned off” in some instances. In parts of India, in an ancient agricultural ritual that is still practiced, villagers hang from hooks embedded in their backs to bless children and crops, yet show no sign of pain. In Africa, India, and other places, trepanation—a type of primitive brain surgery in which a hole is drilled into a patient’s skull—is still practiced without painkillers and no outward appearance of distress on the part of the patients.

Our interpretation of pain is also influenced by past experiences, state of mind, expectations, culture, family, and the “meaning” ascribed to the pain. One of the best examples is childbirth, which women endure and repeat for the obvious benefit at the end. Childbirth is so painful, it is said facetiously, that if men had to go through it, the human species would “die out.”

Our interpretation of pain is also influenced by past experiences, state of mind, expectations, culture, family, and the ‘meaning’ ascribed to the pain.

In my years of practice, I have had the opportunity to see and participate in the rehabilitation of more than 10,000 patients with chronic or persistent pain. Most of these patients have not responded to treatment with medications, surgery, anesthesia interventions, prescription drugs (mainly opioids/narcotics), and are still seeking a “cure.”

Sadly, there is no “cure” for chronic pain, but it can be well managed and patients can have a high quality of life. When patients receive multidisciplinary treatment—which provides a cafeteria of different approaches like physical therapy, exercises, psychological support, and medication when needed—they almost invariably get better.

Through active participation in their treatment and embracing a new attitude, most patients learn effective self-care, self-efficacy, and self-management of their pain and go on to live useful lives.

Last year, a federal advisory group made up of the Food and Drug Administration (FDA), National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), Departments of Defense and Veterans Affairs, and the Agency for Healthcare Research and Quality, released a National Pain Strategy plan to address America’s problem with chronic pain. The proposal, based on multidisciplinary treatment and addressing the biological, psychological, and social factors behind chronic pain, is good news for patients and the clinicians who treat them.

Dr. Sridhar Vasudevan. (Courtesy of Springer)

Dr. Sridhar Vasudevan. (Courtesy of Springer)

Sridhar Vasudevan, M.D., is a clinical professor of physical medicine and rehabilitation at the Medical College of Wisconsin in Milwaukee. This is an excerpt from “Multidisciplinary Management of Chronic Pain: A Practical Guide for Clinicians,” available from the global publishing company Springer.

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