The Indians pounded Yankees starter Wang Chien-ming and reliever Anthony Claggett for 13 of their 25 hits in the second inning on a day when every starter in the Cleveland lineup enjoyed at least one hit.
Cleveland sent 17 batters to the plate in the second inning with nine successively reaching base at one point.
"No one cared how long the inning was," Mark DeRosa told reporters after notching four hits to drive in six runs.
"When you're getting hits and scoring runs, you'll stay at the park all day."
Asdrubal Cabrera had a grand-slam home run, Choo Shin-soo hit a three-run homer and Grady Sizemore had a solo homer for the Indians in the inning.
The Yankees had never before allowed 14 runs in an inning, while the 22 scored against also matched the record at home games, the New York Times said on its website (www.nytimes.com).
Wang, who held the Indians scoreless in the first, took eight of the 14 runs, including Choo's three-run homer, as his record slumped to 0-3 and his earned run average to 34.50. He yielded eight hits in 1 1/3 innings.
"Usually, (Wang) throws 94-96 (mph)," Choo said. "Today, he was 88-90."
Yankees manager Joe Girardi insisted Wang, who tore a ligament in his foot last June, was not hurt.
Wang has now permitted 23 earned runs in six innings this season.
"Mostly I could keep my sinkers down," Wang said through an interpreter. "But when I left a few up, they hit them hard."
