Kobe Bryant and Pau Gasol each scored 23 points as the Lakers snapped the Spurs' three-game winning streak. Michael Finley and Tony Parker had 25 points apiece for San Antonio.
It was the Lakers' (52-13) second impressive road victory in as many nights having knocked off the Houston Rockets 102-96 Wednesday.
Bryant had a big part to play in Thursday's win with a clutch three-pointer that put the Lakers up 98-93 with 1:46 to go.
Los Angeles forward Lamar Odom, who returned from a one-game suspension for leaving the bench during an altercation against Portland Monday, recorded 12 points and 10 rebounds.
All-Star forward Tim Duncan finished with 16 points and 11 rebounds for the Spurs, who fell to 43-21 with the loss.
