The All-Star forward filled out the stat-sheet with seven rebounds, six assists, four steals and three blocks as Cleveland improved their league-best record to 29-6.
The struggling Celtics (29-9) were led by Kevin Garnett, who had 18 points and 15 rebounds, but could not prevent his team from losing for a fourth straight game and for the seventh time in the last nine contests.
Last season, the Celtics defeated the Cavaliers 4-3 in the best-of-seven Eastern Conference semi-finals, but an improved Cleveland appears ready to lay claim to the conference crown.
Mo Williams, acquired in the off-season to provide the team with added scoring, had 13 points while Anderson Varejao had 14 and nine rebounds as the Cavaliers lifted their perfect home record to 19-0.
